Results 41 to 50 of about 111,277 (303)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of an Adaptive Serious Game System for Facial Paralysis Rehabilitation: A Facial Movement Recognition Pilot Study

IEEE Transactions on Neural Systems and Rehabilitation Engineering
In recent years, motion-capture technologies have been widely applied in rehabilitation to enhance patient engagement and therapeutic efficacy. Facial paralysis, characterized by impaired facial muscle function due to facial nerve injury, is typically ...
Mengchen Zhang, Yiran Sun, Xing Sun
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Functional characterization of orbicularis oculi and extraocular muscles [PDF]

, 2016
The orbicularis oculi are the sphincter muscles of the eyelids and are involved in modulating facial expression. They differ from both limb and extraocular muscles (EOMs) in their histology and biochemistry. Weakness of the orbicularis oculi muscles is a
Zorzato, Francesco, Sekulic-Jablanovic, M, Ullrich, Nina D., Zorzato, F, Goldblum, D, Sekulic-Jablanovic, Marijana, Goldblum, David, Treves, Susan, Palmowski-Wolfe, Anja, Ullrich, ND, Palmowski-Wolfe, A, Treves, S   +11 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Magnetic Resonance Imaging Volumetry of Facial Muscles in a Face Transplant Recipient

Plastic and Reconstructive Surgery, Global Open, 2019
Summary:. Face transplantation has evolved into a viable reconstructive option for patients with extensive facial disfigurement. Because the first face transplant procedure was described in 2005, the safety and feasibility of the procedure have been ...
Rami S. Kantar, MD, MPH, Nicole Wake, PhD, Allyson R. Alfonso, BS, BA, William J. Rifkin, MD, Elie P. Ramly, MD, J. Rodrigo Diaz-Siso, MD, Eduardo D. Rodriguez, MD, DDS   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Facial expression recognition through muscle synergies and estimation of facial keypoint displacements through a skin-musculoskeletal model using facial sEMG signals

Frontiers in Bioengineering and Biotechnology
The development of facial expression recognition (FER) and facial expression generation (FEG) systems is essential to enhance human-robot interactions (HRI). The facial action coding system is widely used in FER and FEG tasks, as it offers a framework to
Lun Shu, Victor R. Barradas, Zixuan Qin, Yasuharu Koike   +3 more
doaj   +1 more source

Comparative Study of Multimodal Therapy in Facial Palsy Patients

Archives of Plastic Surgery, 2022
Introduction In chronic facial palsy, synkinetic muscle overactivity and shortening causes muscle stiffness resulting in reduced movement and functional activity.
Catriona Neville, Tamsin Gwynn, Karen Young, Elizabeth Jordan, Raman Malhotra, Charles Nduka, Ruben Yap Kannan   +6 more
doaj   +1 more source