Results 61 to 70 of about 2,236,434 (321)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Sparsity in Dynamics of Spontaneous Subtle Emotions: Analysis \& Application

, 2016
Spontaneous subtle emotions are expressed through micro-expressions, which are tiny, sudden and short-lived dynamics of facial muscles; thus poses a great challenge for visual recognition.
Ngo, Anh Cat Le, Phan, Raphael Chung-Wei, See, John   +2 more
core   +1 more source

Control of echolocation pulses by neurons of the nucleus ambiguus in the rufous horseshoe bat, Rhinolophus rouxi [PDF]

, 1986
1. Horseradish peroxidase was applied by iontophoretic injections to physiologically identified regions of the laryngeal motor nucleus, the nucleus ambiguus in the CF/FM batRhinolophus rouxi. 2.
Rübsamen, R., Schweizer, Hermann
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Chimpanzees (Pan troglodytes) produce the same types of ‘laugh faces’ when they emit laughter and when they are silent [PDF]

, 2015
The ability to flexibly produce facial expressions and vocalizations has a strong impact on the way humans communicate, as it promotes more explicit and versatile forms of communication. Whereas facial expressions and vocalizations are unarguably closely
Bard, Kim A., Davila-Ross, Marina, Jesus, Goncalo, Osborne, Jade   +3 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Contrasting Experimentally Device-Manipulated and Device-Free Smiles. [PDF]

, 2019
Researchers in psychology have long been interested in not only studying smiles, but in examining the downstream effects of experimentally manipulated smiles.
Cross, Marie P, Gheorma, Liana, Pressman, Sarah D   +2 more
core  

Molecular and cellular mechanisms underlying the evolution of form and function in the amniote jaw. [PDF]

, 2019
The amniote jaw complex is a remarkable amalgamation of derivatives from distinct embryonic cell lineages. During development, the cells in these lineages experience concerted movements, migrations, and signaling interactions that take them from their ...
A Abzhanov, A Abzhanov, A Abzhanov, A Baggiolini, A Baroffio, A Beverdam, A Chevallier, A Davidian, A del Rio, A Graham, A Graham, A Hosseini, A Rinon, A Roycroft, A Sharir, A Shellard, A Subramanian, AA Pitsillides, AE Adams, AE Merrill, AG Robling, AG Robling, AH Jheon, AJ Hughes, AL Romanoff, AL Tavares, ALP Tavares, AM Bailleul, AM Bailleul, AM Lucas, AS Pollard, AS Romer, AS Romer, AS Tucker, AS Tucker, AW Crompton, AW Crompton, B Christ, B McBratney-Owen, B Ruhin, BA Moore-Scott, BD Matthews, BF Eames, BF Eames, BF Kingsbury, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BK Hall, BL Pruitt, C Attanasio, C Gans, C Gegenbaur, C Holliday, C Mitgutsch, C Patterson, C Reichert, CI Lorda-Diez, CL Hammond, CS Le Lievre, CS Le Lièvre, CT Miller, CV Baker, CV Baker, CW Benkman, CW Benkman, D Hu, D Hu, D Hu, D Hu, D Noden, DD Davis, DE Clouthier, DG Wilkinson, DJ Evans, DL Stemple, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DM Noden, DR Carter, DR Cordero, E Berthet, E Blitz, E Blitz, E Dupin, E Gaupp, E Jarvik, E Theveneau, E Tzahor, E Tzahor, E Zelzer, EC Olesnicky Killian, EF Allin, EL Ealba, EM Sefton, EP Allis, EP Allis, EP Allis, ER Lankester, ES Goodrich, ES Goodrich, ES Russell, F Lescroart, F Liu, FJ Smith, FL Landacre, FV Jotereau, FW Chamberlain, G Andres, G Balooch, G Couly, G Couly, G Couly, G Kardon, G Kardon, G Köntges, G Wagner, G Zweers, GA Zweers, GA Zweers, GA Zweers, GB Muller, GF Couly, GF Couly, GM Morriss-Kay, GR de Beer, GR de Beer, GR de Beer, H Vinkka, HB Shaffer, HJ Chong, HL Hamilton, HL Szabo-Rogers, HP Shih, I Bothe, I Raizman, I Rot-Nikcevic, J Apostolakos, J Fang, J Grenier, J Hall, J Jeong, J Kahn, J Ruberte, J Stutzmann, JA Helms, JB Gross, JB Platt, JF Webb, JJ Baumel, JJ Schoenebeck, JJ Schoenebeck, JL Chang, JL Fish, JL Fish, JL Fish, JL Fish, JM Brito, JM Richman, JM Tabler, JN Thompson, JP Golding, JR Merida-Velasco, JR Merida-Velasco, JR Robbins, JS Kingsley, JW Kingsbury, K Hayashi, K Sheehan-Rooney, K Yasui, KC Woronowicz, KC Wu, KE Haworth, KJ Lamb, KK Smith, KK Smith, KK Smith, KK Smith, KS Thomson, KW Li, KW Tosney, L LeResche, L Olsson, L Ramage, LB Ruest, LS Gammill, LS Stone, LS Stone, M Bancroft, M Benjamin, M Bronner-Fraser, M Bronner-Fraser, M Hoso, M Jollie, M Jollie, M Jollie, M Jollie, M Linde-Medina, M Minoux, M Persson, M Qiu, M Qiu, M Sieber-Blum, M Simoes-Costa, M Takechi, M Tokita, M Tokita, MA Selleck, MA Shkoukani, MAJ Selleck, MJ Depew, MJ Depew, MJ Depew, MJ Depew, ML Martik, ML Moss, ML Moss, MM Dawson, MM Smith, MM Smith, MN Spyropoulos, MR Sanchez-Villagra, MR Sánchez-Villagra, MS Tyler, MSY Lee, N Anthwal, N Anthwal, N Anthwal, N Wang, NC Jones, NJ Giori, NM Young, NM Young, NN Soni, NS Bradley, O Campas, O Rieppel, OP Hamill, P Betancur, P Danaisawadi, P Hunt, P Kissel, P Kulesa, P Murray, P Murray, P Thorogood, P Wu, P Wu, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PA Trainor, PD Henion, PDF Murray, PH Francis-West, PS Verma, PY Lwigale, R Cerny, R Derynck, R Diogo, R Luo, R Mallarino, R McBeath, R McLennan, R McLennan, R Owen, R Owen, R Presley, R Presley, R Sambasivan, R Sambasivan, R Schweitzer, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Schneider, RA Yuodelis, RC Garcez, RC Mootoosamy, RC Solem, RG Harrison, RG Northcutt, RG Northcutt, RJ Gorlin, RL Carroll, RL Zusi, RW Oppenheim, RW Oppenheim, RW Oppenheim, RW Shufeldt, S Alappat, S Amin, S Creuzet, S Dupont, S Ekanayake, S Hörstadius, S Kavumpurath, S Krispin, S Kuraku, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Kuratani, S Lamichhaney, S Lautenschlager, S Lautenschlager, S Murakami, S Shibata, S Tajbakhsh, S Thomopoulos, S Wadhwa, SC Ahlgren, SC Ahlgren, SH Lee, SH Reynolds, SJ Gould, SJ Mathew, SL Horowitz, SL Prescott, SL Washburn, SR Roberts, SW Herring, T Hems, T Hirasawa, T Kantomaa, T Maeda, T Mammoto, T Matsuoka, T Miyashita, T Rowe, T Sato, T Sauka-Spengler, T Sauka-Spengler, T Square, T Thomas, T Yoshida, TA Appel, TA Mitsiadis, TA Mitsiadis, TC Fitzgerald, TE Parsons, TG Boyd, TH Huxley, TH Huxley, TL Vincent, V Govindarajan, V Hamburger, V Hamburger, V Shone, VL Naples, W Maier, WA Beresford, WA Beresford, WE Reif, WF Van den Heuvel, WG Hall, WJ Moore, WJ Moore, WK Parker, WM McLeod, X Jiang, X Li, XL Tu, Y Hashimoto, Y Shigetani, Y Shigetani, Y Shwartz, Y Song, Y Sugimoto   +395 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source