Results 251 to 260 of about 263,524 (381)

Extreme lateral infrajugular transtubercular exposure for resection of a glomus jugulare: Microsurgical operative video. [PDF]

Surg Neurol Int
Dowlati E, Gensler R, Golub D, Turpin J, White TG, Patsalides A, Costantino PM, Dehdashti AR.   +7 more
europepmc   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, EarlyView.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Practice Patterns in Management of Low- to Intermediate-Grade Salivary Gland Carcinoma: A Multi-Institutional Study. [PDF]

Laryngoscope Investig Otolaryngol
Sajisevi M, Nguyen K, Callas P, Holcomb AJ, Vural E, Davis KP, Thomas CM, Stein JS, Asarkar A, Aulet R, Bell RK, Blasco MA, Bowmaster VB, Burruss CP, Chung J, Chan K, Chang BA, Coffey CS, Cognetti DM, Cooper DJ, Cordero J, Donovan J, Du YJ, Dundar Y, Dedivitis R, Edwards H, Erovic BM, Eskander A, Feinberg PA, Garvey EA, Goldstein D, Goodman JF, Goulart RN, Goyal N, Grasl S, Giurintano J, Gupta N, Habib A, Hackman T, Hara JH, Henson C, Hinni ML, Hua N, Johnson-Obaseki S, Juloori A, Kalman NS, Kejner A, Khaja SF, Ku JA, Lambert A, Luu BK, Magliocca KR, Medina Dos Santos LR, Michael C, Miles B, de Melo GM, Moore MG, Morand GB, Moura K, Noroozi H, Patel R, Paydarfar J, Plonowska-Hirschfeld KA, Sadeghi N, Savaria F, Schmitt NC, Shapiro J, Shaver TB, Stoeckli SJ, Stokes WA, Sulibhavi A, Tasoulas J, Vendra V, Vinh DB, Virgen CG, Woody NM, Young GD, Kakarala K, Enepekides DJ, Hier MP, Davies L, Ryan WR.   +81 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Neurosarcoidosis With Cranial Nerve Polyneuropathy: A Case Report Highlighting the Potential Role of Serial Systemic Immune-Inflammatory Indices (SSIIi). [PDF]

Cureus
Beggerow R, De Silva M, Wijeratne T.
europepmc   +1 more source

Cell Fate Determination and Lineage Tracing: Technological Evolution and Multidimensional Applications

Advanced Science, EarlyView.
This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen, Zhicong Liu, Qiang Shu, Bin Zhou   +3 more
wiley   +1 more source

Nasopharyngeal Giant Carcinoma Mimicking Intracranial Lesions: A Case Report and Literature Review. [PDF]

Am J Case Rep
Zilan Y, Ye Z.
europepmc   +1 more source

Diagnosis, Prognosis, and Drug Target Discovery for Chronic Widespread Pain: A Large Proteogenomic Study

Advanced Science, EarlyView.
Plasma proteomics is leveraged to decode the biological underpinnings of chronic widespread pain. A nested machine learning framework integrates proteomic signatures, prospective outcomes, and Mendelian randomization to uncover 18 causal proteins.
Li Chen, Eoin Kelleher, Ruogu Meng, Duanke Liu, Yuchen Guo, Yunhe Wang, Yaqing Gao, Zhe Huang, Zhu Liang, Shuai Yuan, Chao Zeng, Jun Ma, Yanhui Dong, Anushka Irani, Guanghua Lei, Junqing Xie, Daniel Prieto‐Alhambra   +16 more
wiley   +1 more source

Isolated Abducens Nerve Palsy in an Adolescent With Confounding Multisystem Serology: A Case Report and Diagnostic Review. [PDF]

Case Rep Pediatr
Paparella R, Bernabei I, Panvino F, Ajassa C, Benedetti L, Leonardi L, Spalice A, Tarani L.   +7 more
europepmc   +1 more source

Next‐Generation Piezoelectric Materials in Wearable and Implantable Devices for Continuous Physiological Monitoring

Advanced Science, EarlyView.
An analysis of literature trends and a historical overview of organic and inorganic piezoelectric materials, focusing on their structural diversity, functional mechanisms, and inherent characteristics. It then explores cutting‐edge developments in material synthesis, fabrication processes, and performance optimization, highlighting their applicability ...
Bangul Khan, Umay Amara, Bilawal Khan, Wasim Ullah Khan, Rafi u Shan Ahmad, Muhammad Shehzad Khan, Mohamed Elhousseini Hilal, Bee Luan Khoo   +7 more
wiley   +1 more source