Results 31 to 40 of about 51,157 (264)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Facial nerve regeneration via body-brain crosstalk: The role of stem cells and biomaterials

Neurobiology of Disease
The human body is a complex, integral whole, and disruptions in one organ can lead to dysfunctions in other parts of the organ network. The facial nerve, as the seventh cranial nerve, arises from the brainstem, controls facial expression muscles and ...
Yuping Xie, Chuan Ma, Qiang Zhu, Ting Fu, Long Bai, Xiaorong Lan, Lin Liu, Jingang Xiao   +7 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Facial nerve reconstruction for flaccid facial paralysis: a systematic review and meta-analysis

Frontiers in Surgery
ObjectivesTo determine the functional outcome after facial nerve reconstruction surgery in patients with flaccid facial paralysis.MethodsA systematic review and meta-analysis was performed on studies reporting outcomes after direct facial nerve suture ...
Friedemann Zumbusch, Peter Schlattmann, Orlando Guntinas-Lichius, Orlando Guntinas-Lichius, Orlando Guntinas-Lichius   +4 more
doaj   +1 more source

Long term results of idiopathic hemifacial palsy: Orthodontic and surgical multidisciplinary management

Oral and Maxillofacial Surgery Cases, 2017
Idiopathic facial palsy is the most common cause of unilateral neurologic disorders of the cranial nerves.It can result from congenital, due to delivery traumas, and genetic or malformative diseases, or acquired due to infective, inflammatory, neoplastic,
Cinzia Maspero, Marco Farronato, Guia Guenza, Davide Farronato   +3 more
doaj   +1 more source

Pediatric parotidectomy outcomes: A 14‐year multicenter study

Laryngoscope Investigative Otolaryngology, 2022
Objectives Parotidectomy increases childhood challenges. This study aimed to determine the clinical profiles, investigations, and outcomes of pediatric patients who had undergone parotidectomy.
Napadon Tangjaturonrasme, Wisarut Samuckkeethum, Hanpon Klibngern, Narin Ratanaprasert, Jakkree Naruekon, Kitti Jantharapattana   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Peripheral facial nerve palsy as a manifestation of neuroborreliosis in children

Pediatria i Medycyna Rodzinna, 2019
Lyme disease, also known as Lyme borreliosis, is a systemic infectious disease caused by Borrelia burgdorferi spirochetes. It is spread by the bites of infected ticks of the genus Ixodes which inhabit forest plants in the northern hemisphere, including ...
Monika Zielińska, Rafał Zieliński
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source