Results 41 to 50 of about 79,167 (297)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Effect of nasogastric tube feeding on oral wound healing and oral health-related quality of life (OHRQoL) after surgery for medication-related osteonecrosis of the jaw (MRONJ)

Head & Face Medicine
Background In patients with medication-related osteonecrosis of the jaw (MRONJ), the use of nasogastric tubes (NGTs) after surgery is recommended to allow adequate nutrition without food interfering with oral wound healing.
Luise Surmann, Julian Lommen, Valentin Kerkfeld, Max Wilkat, Rita Depprich, Henrik Holtmann, Majeed Rana, Norbert R. Kübler, Lara Schorn   +8 more
doaj   +1 more source

A New Computer-aided Technique for Planning the Aesthetic Outcome of Plastic Surgery [PDF]

, 2008
Plastic surgery plays a major role in today health care. Planning plastic face surgery requires dealing with the elusive concept of attractiveness for evaluating feasible beautification of a particular face.
Bottino, Andrea Giuseppe, Laurentini, Aldo, Rosano, Luisa   +2 more
core   +1 more source

Accuracy of generic mesh conformation: the future of facial morphological analysis [PDF]

, 2017
Three-dimensional (3D) analysis of the face is required for the assessment of changes following surgery, to monitor the progress of pathological conditions and for the evaluation of facial growth.
Almukhtar, A., Ayoub, A., Ju, X., Khambay, B., McDonald, J.   +4 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Fracture heat map of the facial skull demonstrates a danger zone of concomitant cervical spine injuries

Scientific Reports, 2021
Concomitant maxillofacial and cervical spine injuries occur in 0.8–12% of the cases. We examined the relation of injury localization and the probability of cervical spine fracture. A retrospective study was conducted on patients that have been treated at
Ákos Bicsák, Robert Sarge, Oliver Müller, Stefan Hassfeld, Lars Bonitz   +4 more
doaj   +1 more source

The Isolated Orbital Floor Fracture from a Transconjunctival or Subciliary Perspective-A Standardized Anthropometric Evaluation [PDF]

, 2015
Background: The influence of orbital fractures and their repair on the rate of deformities of the lower eyelid is an ongoing source of discussion in the literature.
Djedovic, Gabriel, Gomez-Dammeier, Marta, Guentsch, Arndt, Peisker, Andre, Raschke, Gregor F., Rieger, Ulrich M., Schultze-Mosgau, Stefan, Wohlrath, Rene   +7 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Impact of quality certification of multidisciplinary head and neck tumor centers

Cost Effectiveness and Resource Allocation, 2021
Background Certification of multidisciplinary tumor centers is nowadays seen as the gold standard in modern oncological therapy for optimization and realization of guideline-based therapy and better outcomes.
Ali Modabber, Daniel Schick, Evgeny Goloborodko, Florian Peters, Marius Heitzer, Anna Bock, Kristian Kniha, Frank Hölzle, Elke M. Schreiber, Stephan Christian Möhlhenrich   +9 more
doaj   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source