Results 71 to 80 of about 4,357,032 (304)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Dearq, 2012 This paper analyses the origins and the management of religious facilities in Spain within a process of urbanization with the promotion of housing estates.
Esteban Fernández Cobián +1 more
doaj
Evaluation of Infrastructure, Facilities and Public Utilities (IFP) in Urban Infrastructure Development (Case Study: Urban Area of Lut Tawar District, Central Aceh, Aceh, Indonesia) [PDF]
E3S Web of ConferencesIn Central Aceh District Head Regulation Number 47 of 2021 Concerning Detailed Spatial Plans for the Takengon Urban Area in Central Aceh District for 2020-2040, the Takengon Urban Area consists of 3 (three) District areas and 47 (Forty Seven) Village ...
Ahmadsyah +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Joint investments of the real economy and healthcare institutions in the Republic of Serbia [PDF]
Ekonomija: teorija i praksaThe study presents the importance of joint financial investment between two forms of organizing the economy, more precisely between the real economy and healthcare with the aim of improving both business and the provision of health services to the ...
Čolović Mrđan +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mimbar Sekolah Dasar, 2019 This research aims at revealing the effect of educational facilities and infrastructure in primary schools on students’ learning outcomes. This was based on the Education Data Centre (Dapodik – Data Pokok Pendidikan) of 2017/2018 Academic Year stating ...
Nugrahana Fitria Ruhyana, Ani Nur Aeni
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source