Results 31 to 40 of about 434,300 (226)

Dynamic Maintenance Cost Optimization in Data Centers: An Availability-Based Approach for K-out-of-N Systems

Buildings
Data Centers (DCs) are critical infrastructures that support the digital world, requiring fast and reliable information transmission for sustainability.
Mostafa Fadaeefath Abadi, Mohammad Javad Bordbari, Fariborz Haghighat, Fuzhan Nasiri   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Building Information Model (BIM) use analysis in facilities management

Mokslas: Lietuvos Ateitis, 2021
This paper presents the analysis of Building Information Model usage in Facilities Management. The main Facility Management aspects and problems are analyzed and advantages and disadvantages of Building Information Model are evaluated, opinions about BIM
Eglė Vaičiulytė
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modeling Deep Neural Networks to Learn Maintenance and Repair Costs of Educational Facilities

Buildings, 2021
Educational facilities hold a higher degree of uncertainty in predicting maintenance and repair costs than other types of facilities. Moreover, achieving accurate and reliable maintenance and repair costs is essential, yet very little is known about a ...
Jimyong Kim, Sangguk Yum, Seunghyun Son, Kiyoung Son, Junseo Bae   +4 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

State of the art in work zone safety: A systematic review

International Journal of Transportation Science and Technology
The ever-increasing number of accidents is detrimental to the sustainable objectives of work zones. Exploring the causes for work zone safety (WZS) issues, countermeasures, and effectiveness is significant to enhance the WZS.
Nimali Rathnasiri, Nayanthara De Silva, Janaka Wijesundara   +2 more
doaj   +1 more source

Organisational Justice Analysis of Facility Managers’ Responses to User’s Post-Occupancy Feedback

Buildings, 2021
There has been growing interest in how to foster collaborative relationships between facility managers and end-users to obtain user-centred post-occupancy data for improving design and user satisfaction.
Abiodun Olatunji Abisuga, Cynthia Changxin Wang, Riza Yosia Sunindijo   +2 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source