Results 51 to 60 of about 9,487,770 (289)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The dangers of urban decline and the role of facility management in reducing associated safety and health risks

, 2020
Background and aim – This paper studies urban decline, the process in which the built environment suddenly or gradually loses its practical, technical and economic functionality, resulting in it being abandoned by its legitimate occupants and neglected ...
Netten, Hans, Mobach, Mark P., Nijkamp, Jeannette E., Jylhä, Tuuli   +3 more
core  

Risikoanalyse und -bewertung für Facility Management-Prozesse während der Immobiliennutzungsphase

Journal für Facility Management, 2009
In ihrer gegenwärtigen Forschungsarbeit beschäftigen sich die Autoren mit der Fragestellung, Risiken in Facility Management-Prozessen während der Immobiliennutzungsphase zu identifizieren und Strategien zu ihrer Bewältigung aufzuzeigen.
Bockstefl, Johannes, Redlein, Alexander
doaj  

A Text-Based Predictive Maintenance Approach for Facility Management Requests Utilizing Association Rule Mining and Large Language Models

Machine Learning and Knowledge Extraction
Introduction: Due to the lack of labeled data, applying predictive maintenance algorithms for facility management is cumbersome. Most companies are unwilling to share data or do not have time for annotation.
Maximilian Lowin
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Facilities Management [PDF]

, 2018
Afsnittet ”Facilities Management” (FM) giver en kort introduktion til fagområdet FM med særligt fokus på bygningsdrift. Afsnittet beskæftiger sig desuden med FM i relation til byggeprojekter og giver konkrete eksempler på hvordan viden om bygningsdrift bør inddrages tidligt i byggeprojekter for at bidrage til at byggerier projekteres så driftsvenligt ...
Elizabeth Lewis, Olivier Chamel, Mahsan Mohsenin, Enn Ots, Edward T. White   +4 more
openaire   +2 more sources

Wirtschaftlichkeit von Facility Management - Entwicklungen und Trends

Journal für Facility Management, 2018
Das vorliegende Paper baut auf den jährlichen Umfragen bzw. Studien des Immobilien und Facility Management (IFM) der Technischen Universität Wien (TU Wien) und der Dissertation von Susanne Hauk aus dem Jahr 2007 auf.
Redlein, Alexander, Zobl, Michael, Getzner, Michael   +2 more
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Interactive Facility Management, Design and Planning [PDF]

, 2012
Societal developments show that future demands for visualization can be expected to grow. In many areas of organized human activities organizations may turn away from textual and numerical flatlands, and rely on the convenient and multidimensional ...
Mobach, M.P., Mobach, Mark P., Mark P. Mobach   +2 more
core   +1 more source

Raumklima im Büro und Wohlbefinden: gesetzliche Anforderungen und Vergleich mit einem Gebäudezertifizierungssystem

Journal für Facility Management, 2016
Room climate is a fundamental factor for human wellbeing. Laws and standards define the ‘state of art for room climate parameters. To know this state of art helps us, to understand better the influence of environmental factors on human wellbeing.
Redlein, Alexander, Hax-Noske, Christine
doaj