Results 21 to 30 of about 1,084,277 (249)
Simulator Semantics for System Level Formal Verification [PDF]
, 2015 Many simulation based Bounded Model Checking approaches to System Level Formal Verification (SLFV) have been devised. Typically such approaches exploit the capability of simulators to save computation time by saving and restoring the state of the system ...
Mancini, Toni +4 more
core +4 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Finding Streams in Knowledge Graphs to Support Fact Checking
, 2017 The volume and velocity of information that gets generated online limits current journalistic practices to fact-check claims at the same rate. Computational approaches for fact checking may be the key to help mitigate the risks of massive misinformation ...
Ciampaglia, Giovanni Luca +3 more
core +1 more source
Correcting political and consumer misperceptions [PDF]
, 2016 While fact-checking has grown dramatically in the last decade, little is known about the relative effectiveness of different formats in correcting false beliefs or overcoming partisan resistance to new information.
Amazeen, Michelle A. +3 more
core +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Estimating Fact-checking's Effects: Evidence From a Long-term Experiment During Campaign 2014 [PDF]
, 2015 This study reports the first experimental estimates of the longitudinal effects of exposure to fact-checking. We also conduct a comprehensive panel study of attitudes toward fact-checking and how they change during a campaign.Our results are generally ...
Brendan Nyhan, Jason Reifler
core
Hoaxy: A Platform for Tracking Online Misinformation
, 2016 Massive amounts of misinformation have been observed to spread in uncontrolled fashion across social media. Examples include rumors, hoaxes, fake news, and conspiracy theories.
Ciampaglia, Giovanni Luca +3 more
core +1 more source