FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Capitalismo social: un vistazo a resultados macroeconómicos de Ecuador, Perú y Colombia
Retos: Revista de Ciencias de la Administración y Economía, 2017 Adam Smith afirmaba que el egoísmo individual es el que lleva a generar riqueza y al crecimiento económico de las naciones. Con un capitalismo naciente a raíz de la colonización de las Américas, la formación de una clase empresarial ávida de dinero, que ...
Roma Amada Lalama, Andres Bravo Lalama
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis [PDF]
, 1999 Zhiwei Li +7 more
openalex +1 more source
Why emerging leaders should focus on being good postdoctoral supervisors
FEBS Letters, EarlyView.Swamped with work and suddenly a new student is waiting at your doorstep for supervision? Great—this is your chance! In this article, we share tips on how postdocs can strengthen their leadership skills while supervising students. This image has been created using DALL·E. Many postdocs work as leaders later in their career.
Hannah Rostalski +5 more
wiley +1 more source
Graphical representation of hydrogen bonding patterns in proteins [PDF]
, 2017 A graphical representation of the intramolecular hydrogen bonding in a protein is described, which provides a direct and easily interpretable display of its secondary and tertiary structural elements.
Factor, A.D., Mehler, E.L.
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Global factor trade with differentiated factor prices and factor intensities [PDF]
Canadian Journal of Economics/Revue canadienne d'économique, 2006 Abstract Relaxing the assumption of internationally identical factor intensity techniques in the HOV model creates two challenges. First, computing actual factor intensity techniques of different countries requires detailed input‐output tables and factor usage data, which are not always available.
openaire +2 more sources
Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B. [PDF]
, 1998 Claudia Wahl +3 more
openalex +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Farm Level Capital: Capital positions, structures, the dynamics of farm level investments, capital accumulation and leverage positions [PDF]
This paper aims to describe and highlight the key issues of farm capital structures, the dynamics of investments and accumulation of farm capital, and the financial leverage and borrowing rates on farms in selected European countries. Data collected from
Heikkilä, Anna-Maija +2 more
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