Results 101 to 110 of about 20,236,854 (354)
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
"It's wrong - but you get used to it" : a qualitative study of gang-associated sexual violence towards, and exploitation of, young people in England [PDF]
, 2013 A report commissioned by the Office of the Children’s Commissioner’s Inquiry into Child Sexual Exploitation in Gangs and GroupsThe research was commissioned by the Office of the Children’s Commissioner for England as part of its Inquiry into Child ...
Beckett, Helen +7 more
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
, 2012 Factorial clustering methods have been developed in recent years thanks to the improving of computational power. These methods perform a linear transformation of data and a clustering on transformed data optimizing a common criterion.
A. Ben-Israel +6 more
core +2 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
This issue of Play and Folklore has a special focus on children’s outdoor play. We hear many stories about the constraints placed on children’s play by adults – the growing number of ‘bannings’ include handstands, cartwheels, throwing things, playing ...
Gwenda Beed Davey +2 more
core
, 2017 Bayesian sparse factor models have proven useful for characterizing dependence in multivariate data, but scaling computation to large numbers of samples and dimensions is problematic. We propose expandable factor analysis for scalable inference in factor
Dunson, David B. +2 more
core +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Packings, factors and factorizations of graphs
, 1992 Bibliography: p. 93-95.
openaire +3 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source