Results 131 to 140 of about 21,871,150 (353)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Risk Factors for High Mortality on the Liver Transplant Waiting List in Times of Organ Shortage: A Single-Center Analysis

, 2019
Peri Husen, Julian Hornung, Tamás Benkö, Christian Klein, Katharina Willuweit, Matthias Buechter, Fuat H. Saner, Andreas Paul, Juergen Treckmann, Dieter P. Hoyer   +9 more
openalex   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Suicide among youth and young adults in Canada: bereaved parents’ perspectives on the systems of care

International Journal of Mental Health Systems
Background Suicide is the second leading cause of death among youth and young adults aged 15–24 in Canada. Emergency departments often serve as the first point of contact for identifying suicide risk, particularly for youth and young adults, partly due ...
Toula Kourgiantakis, Deborah Cooper, David Cooper, Shelley Craig, Eunjung Lee, Jori Jones, Carrie K. Y. Lau, Romy-Naïma Tousignant, Jonathan B. Singer, Marjorie Johnstone, Juveria Zaheer   +10 more
doaj   +1 more source

Medical neglect in Canada: a cross-sectional study exploring drivers of substantiation using a national dataset

BMJ Paediatrics Open
Background This study explores child welfare investigations for medical neglect in Canada, focusing on household, family and child characteristics and drivers of substantiated victimisation.Methods Data from the Canadian Incidence Study of Reported Child
Barbara Fallon, Nicolette Joh-Carnella, Ashley Vandermorris, Kate Allan, Kristin Denault   +4 more
doaj   +1 more source

Evaluating Research Activity:Impact Factor vs. Research Factor [PDF]

The Impact Factor (IF) “has moved ... from an obscure bibliometric indicator to become the chief quantitative measure of the quality of a journal, its research papers, the researchers who wrote those papers, and even the institution they work in” ([2], p.
Marco P. Tucci, Silvia Ferrini
core  

Factors Affecting the Performance of Micro and Small Enterprises in Arada and Lideta Sub-Cities, Addis Ababa

, 2012
Admasu Abera
openalex   +1 more source

Erratum to Dynamic stress-intensity factors for finite strip problems [PDF]

, 1973

openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source