Results 281 to 290 of about 21,871,150 (353)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Improving interpupillary distance accuracy in the plusoptix A12R: A distance-dependent correction. [PDF]

J Optom
Rendo-González S, Garcia-Porta N, Arines J.   +2 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Exercise Craving: A Scale Development Study. [PDF]

Health Sci Rep
İlbak İ, Akarsu M, Yasuntimur A, Düz S, Kavalirova G, Cepicka L.   +5 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

An Enhanced Q-Factor Cantilever Resonator in Viscous Liquids Using Strategic Perforation. [PDF]

Micromachines (Basel)
Qu S, Xia C.
europepmc   +1 more source

Factor structure and psychometric properties of an adapted HIV stigma tool for measuring disability-related stigma among smallholder farmers in Western Kenya - Findings from a cross-sectional study. [PDF]

PLoS One
Jeyam A, Schmidt E, Bechange S, Pye S, Okello G, Muuo S, Chege M, Jolley E.   +7 more
europepmc   +1 more source

Psychometric Properties of the Italian Adaptation of the Subjective Cognitive Reserve Questionnaire Based on Modifiable Lifestyle Factors (SCR-Q). [PDF]

Healthcare (Basel)
Fabrizi E, Moret-Tatay C, Terribili C, di Cicco G, Aversa G, Tormos-Muñoz JM, Della Gatta F.   +6 more
europepmc   +1 more source

Development and Psychometric Validation of a Multidimensional Ecological Model-Based Awareness Scale for Patients with Stage 3-4 Chronic Kidney Disease. [PDF]

Healthcare (Basel)
Aylı BI, Erbaydar NP.
europepmc   +1 more source