Results 291 to 300 of about 20,236,854 (354)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Aortic Valve Defect as an Independent Risk Factor for Endothelial Dysfunction. [PDF]

Cells
Malina M, Banasiak W, Doroszko A.
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

A psychometric study of the team psychological safety scale and sport psychological safety inventory in Swedish elite sports. [PDF]

Sci Rep
Lundqvist C, Bermon S, Timpka T.
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Validation of the Chinese version of the financial toxicity scale in patients with wet age-related macular degeneration. [PDF]

J Patient Rep Outcomes
Chen X, Bian H, Wu Z.
europepmc   +1 more source

Development and Psychometric Validation of the Empathy Fatigue Scale (EFS-HP) for Healthcare Professionals in Critical Care Settings. [PDF]

Nurs Crit Care
Okan N, Zengin F, Okan YT, Şahin Y.
europepmc   +1 more source

Friend or foe: assessing the value of animal models for facilitating clinical breakthroughs in complement research. [PDF]

J Clin Invest
Poppelaars F, Holers VM, Thurman JM.
europepmc   +1 more source

Tacrolimus Modulates TGF-β Signaling-Related Genes and MicroRNAs in Human Retinal Pigment Epithelial Cells Activated by Lipopolysaccharide. [PDF]

Int J Mol Sci
Kiełbasińska A, Krysik K, Janiszewska-Bil D, Machaj M, Lelek Z, Sułkowska J, Nawotny-Czupryna O, Grabarek BO.   +7 more
europepmc   +1 more source

On the Use of Elbow Plot Method for Class Enumeration in Factor Mixture Models. [PDF]

Appl Psychol Meas
Sen S, Cohen AS.
europepmc   +1 more source