Results 141 to 150 of about 45,215,530 (368)

Analysis of Risk Factors of Oral Cancer and Periodontitis from a Sex- and Gender-Related Perspective: Gender Dentistry [PDF]

open access: gold, 2022
Federica Di Spirito   +8 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Factor Analysis [PDF]

open access: yesBritish Journal of General Practice, 2018
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Efficacy and safety of zuranolone in major depressive disorder: a meta-analysis of factor effect and dose-response analyses [PDF]

open access: gold, 2023
Yu‐Wei Lin   +7 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts [PDF]

open access: gold, 2020
Matteo Bassetti   +30 more
openalex   +1 more source

Confirmatory Factor Analysis of Farm Size and Performance [PDF]

open access: yes
Replaced with revised version of poster 08/03/10.Farm size, farm performance, SEM models, Agricultural Finance, Farm Management,
Hadrich, Joleen C., Olson, Frayne E.
core   +1 more source

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