Results 201 to 210 of about 25,062,635 (240)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Alpha Factor Analysis

Psychometrika, 1965
A distinction is made between statistical inference and psychometric inference in factor analysis. After reviewing Rao's canonical factor analysis (CFA), a fundamental statistical method of factoring, a new method of factor analysis based upon the psychometric concept of generalizability is described.
Kaiser, Henry F., Caffrey, J.
openaire   +3 more sources

Fisher Discriminant Analysis and Factor Analysis

IEEE Transactions on Pattern Analysis and Machine Intelligence, 1983
We show that information on the inherent structure of multidimensional data derived from a factor analysis procedure is equivalent to information obtained by Fisher discriminant analysis techniques, provided certain conditions, usually required in the factor analysis model, are satisfied.
Giacomo Della Riccia   +1 more
openaire   +4 more sources

Regression and Factor Analysis

Biometrika, 1973
SUMMARY A basic model of factor analysis is employed in the estimation of multiple correlation coefficients and partial regression weights. Estimators are derived for situations in which some or all of the independent variates are subject to errors in measurement.
Lawley, D. N., Maxwell, A. E.
openaire   +2 more sources

Hazards in Factor Analysis

Journal of Chemical Information and Computer Sciences, 1979
Abstract : Principal components and other standard factor analyses can yield misleading results if an assumed subsidiary condition is untrue or if data are missing. Principal components factor analysis is tested for its reliability, using a problem with known answers.
C. Gardner Swain   +2 more
openaire   +2 more sources

Independent Factor Analysis

Neural Computation, 1999
We introduce the independent factor analysis (IFA) method for recovering independent hidden sources from their observed mixtures. IFA generalizes and unifies ordinary factor analysis (FA), principal component analysis (PCA), and independent component analysis (ICA), and can handle not only square noiseless mixing but also the general case where the ...
openaire   +3 more sources

Factor analysis regression

Statistical Papers, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kosfeld, Reinhold   +1 more
openaire   +3 more sources

THE THEORETICAL FOUNDATIONS OF PRINCIPAL FACTOR ANALYSIS, CANONICAL FACTOR ANALYSIS, AND ALPHA FACTOR ANALYSIS

British Journal of Mathematical and Statistical Psychology, 1970
It is shown that PFA, CFA and AFA are particular cases of a scale‐invariant factoring procedure based on variance ratios of certain weighted combinations of variables. Standard derivations in the literature are shown, in contrast, to have unsatisfactory features.
openaire   +2 more sources

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