Results 191 to 200 of about 5,206,551 (296)

Transcriptomic insights into nerve growth factor-associated appositional bone formation in the reparative zone in osteonecrosis of the femoral head. [PDF]

J Orthop Surg Res
Ayabe Y, Yoshino S, Motomura G, Yamaguchi R, Utsunomiya T, Sakamoto K, Nakashima Y.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A potential risk factor associated with acute tumor lysis syndrome in dogs with multicentric lymphoma receiving chemotherapy. [PDF]

J Vet Intern Med
Yamazaki H, Nagai K, Wada Y, Noguchi S, Yamamoto S, Sakai T, Torisu S.   +6 more
europepmc   +1 more source

Downregulation of a transcription factor associated with resistance to Bt toxin Vip3Aa in the invasive fall armyworm. [PDF]

Proc Natl Acad Sci U S A, 2023
Jin M, Shan Y, Peng Y, Wang W, Zhang H, Liu K, Heckel DG, Wu K, Tabashnik BE, Xiao Y.   +9 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Multi-omics integration identifies PGAP3 as a tumor-intrinsic factor associated with CD8⁺ T-cell exclusion in prostate cancer. [PDF]

Front Mol Biosci
Liu W, Li G, Lei Y, Liu H, Wang B, Deng W, Hong Y, Long X.   +7 more
europepmc   +1 more source

Granulocyte Colony-stimulating Factor-associated Aortitis on Gallium Scintigraphy. [PDF]

Intern Med, 2023
Ozaki H, Takemura K, Kizawa R, Yamaguchi T, Komiyama C, Tachi M, Maruno H, Tanabe Y, Suyama K, Miura Y.   +9 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Obesity is a major modifiable factor associated with ER-negative breast cancer: epidemiological and mechanistic evidence from a high-risk cohort. [PDF]

Breast Cancer Res
Elkum N, Al-Zahrani AS, Alraouji NN, Al-Tweigeri T, Aboussekhra A.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source