Results 91 to 100 of about 2,173,509 (248)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Surveying the factor structure and reliability of the Persian version of the Jefferson scale of physician empathy-health care provider student version (JSE-HPS)

حیات, 2015
Background & Aim: Because of the importance of empathy and positive impact on the relationship between patients and health care providers, as well as the lack of valid instrument to assess studentchr('39')s empathy in health domain, this study aimed to ...
Fatemeh Zahra Karimi, Gholamhosein Zarifnejad, Mahboubeh Abdolahi, Ali Ali Taghipour   +3 more
doaj  

Factor structure of teacher-related boredom in EFL classroom: a mini literature review

Frontiers in Education
The attention of researchers in the field of second language acquisition has been drawn to boredom, which was considered as one of the most prevalent and distressing emotions. However, studies delving into the teacher-related foreign language boredom are
Fang Liu, Fang Liu, Hyonsuk Cho
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Development of the Japanese Version of the Test of Self-Conscious Affect-3 (TOSCA-3): A Study among Student and Parent Population

Behavioral Sciences
Objective: The Test of Self-Conscious Affect-3 (TOSCA-3) is a scenario-based measure of self-conscious emotions. We aimed to create an abridged version of the TOSCA-3 that is appropriate for Japanese populations and has a good fit with the data, as well ...
Toshinori Kitamura, Ayako Hada, Yuriko Usui, Yukiko Ohashi   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Psychometric Evaluation of the Swedish Version of the Empathic Experience Scale (EES)

Psychological Test Adaptation and Development
: Background: This study assessed the factor structure and psychometric properties of the Swedish version of the Empathic Experience Scale (EES), a recently developed scale for empathic traits (Innamorati et al., 2019).
Andreas Sarling, Örjan Sundin, Billy Jansson   +2 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Sence of Agency: Concept, Structure, Assessment

Вопросы образования
In recent years, the sense of agency has been the subject of interest for researchers in psychology, economics, sociology, political science, and education. To psychologically measure this phenomenon, Adam Tapal and his colleagues developed and validated
Alena M. Kulyapina, Anna H. Fam, Alena A. Zolotareva   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source