Results 161 to 170 of about 2,253,238 (268)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Examining the Factor Structure of Objective Health Literacy and Numeracy Scales: Large-Scale Cross-Sectional Study. [PDF]

JMIR Public Health Surveill
Moriishi C, Takano K, Oba T, Konishi N, Katahira K, Kimura K.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Assessing the Factor Structure of the Farm/Ranch Stress Inventory in a Sample of LGBTQ+ Farmers Across the United States. [PDF]

Int J Environ Res Public Health
Rivas-Koehl M, Cuthbertson C, Rivas-Koehl D, Codamon A, Billington A.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Investigating the psychometric properties and confirmatory factor structure of the opinions about the gifted and their education as a teacher's attitude scale. [PDF]

Front Psychol
Shateri A, Tahan M, Azari F.
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Examining the factor structure of the 40-item Defense Style Questionnaire among adults with depression: an individual participant data meta-analysis. [PDF]

Res Psychother
Wienicke FJ, Burk WJ, Heinonen E, Lindfors O, Härkänen T, Knekt P, Sarvasmaa S, Dias de Mattos Souza L, Jansen K, Azevedo da Silva R, Nobre Dos Santos É, Dekker JJM, Peen J, Van HL, Perry JC, Van der Veld WM, Soares E, Spijker J, Driessen E.   +18 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Well-being in upper secondary school students: confirming a 15-factor structure and a class-allocated feasibility trial with practice guidance. [PDF]

Front Psychol
Scalas LF, Pedditzi ML, Cuccu S, Fadda D, Marsh HW.   +4 more
europepmc   +1 more source