Results 61 to 70 of about 2,253,238 (268)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Measuring burnout and work engagement: Factor structure, invariance, and latent mean differences across Greece and the Netherlands [PDF]

International Journal of Business Science and Applied Management, 2012
This study examines the factor structure and invariance of the instruments measuring burnout (Maslach Burnout Inventory - General Survey / MBI-GS) and work engagement (Utrecht Work Engagement Scale / UWES) in a sample of Dutch (N = 162) and Greek (N ...
Xanthopoulou, D., Bakker, A.B., Kantas, A., Demerouti, E.   +3 more
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Psychometric properties and factor structure of the satisfaction with life scale in Ecuadorian university students

Frontiers in Psychology
BackgroundThe Satisfaction with Life Scale (SWLS) measures the global cognitive judgment about one’s own life. Although it has been validated in different countries and populations, in the Ecuadorian context, it has not been validated for a university ...
Victor Manuel López-Guerra, Tatiana Isabel Pucha-Loarte, Luisa T. Angelucci, Pablo V. Torres-Carrión   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Motors of COVID-19 Vaccination Acceptance Scale (MoVac-COVID19S): Evidence of Measurement Invariance Across Five Countries [Corrigendum]

Risk Management and Healthcare Policy, 2022
Chen IH, Wu PL, Yen CF, et al. Risk Manag Healthc Policy. 2022;15:435–445. Page 437, Materials and Methods, Participants and Recruitment Procedure, Taiwanese Participants section, last sentence, the text “(IRB ref: KMUHIRB-EXEMPT(I)-20200119)&
Chen IH, Wu PL, Yen CF, Ullah I, Shoib S, Zahid SU, Bashir A, Iqbal N, Addo FM, Adjaottor ES, Amankwaah GB, Ahorsu DK, Griffiths MD, Lin CY, Pakpour AH   +14 more
doaj  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

FRIENDSHIP FUNCTIONS AND PERSONALITY TRAITS [PDF]

Psihologija, 2009
The goal of our study was exploration of the factor structure of the MFQ-FF inventory on a sample from Serbian population, and the relations of measures from this inventory (friendship functions) with personality traits, as operationalized by the seven ...
Ivana Pedovic, Vladimir Hedrih, Jelena Zeleskov Djoric   +2 more
doaj