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Acta Haematologica, 2009
In two patients with the abnormal factor X (factor X Friuli) coagulation disorder a multiple tooth extraction was carried out immediately after the transfusion. X of 4 U of factor X concentrate (Bebulin) equivalent to 2,000 ml of normal plasma. No bleeding was noted. The half-life of the exogeneous component was 30 and 28 h, respectively.
A, Girolami, G, Molaro, L, De Marco
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In two patients with the abnormal factor X (factor X Friuli) coagulation disorder a multiple tooth extraction was carried out immediately after the transfusion. X of 4 U of factor X concentrate (Bebulin) equivalent to 2,000 ml of normal plasma. No bleeding was noted. The half-life of the exogeneous component was 30 and 28 h, respectively.
A, Girolami, G, Molaro, L, De Marco
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Blood Reviews, 2002
Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene.
James, Uprichard, David J, Perry
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Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene.
James, Uprichard, David J, Perry
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Expert Opinion on Investigational Drugs, 2003
Factor X plays a central role in coagulation, being the point of convergence of the extrinsic and intrinsic pathways of blood clotting. It may also act as one of the links between the coagulation and inflammatory pathways. These findings suggest that factor X may represent an attractive target for a new antithrombotic drug. Indeed, a factor X inhibitor,
Kiat Tsong, Tan +2 more
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Factor X plays a central role in coagulation, being the point of convergence of the extrinsic and intrinsic pathways of blood clotting. It may also act as one of the links between the coagulation and inflammatory pathways. These findings suggest that factor X may represent an attractive target for a new antithrombotic drug. Indeed, a factor X inhibitor,
Kiat Tsong, Tan +2 more
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Seminars in Thrombosis and Hemostasis, 2009
Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people. Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and
Marzia, Menegatti, Flora, Peyvandi
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Factor X (FX) deficiency is a rare, recessively inherited bleeding disorder representing 10% of all rare bleeding diseases and affecting 1 in every 1,000,000 people. Its clinical presentation places FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and
Marzia, Menegatti, Flora, Peyvandi
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Thrombosis and Haemostasis, 1971
SummaryA monospecific antiserum against factor X was prepared in rabbits. The antiserum precipitated factor X in human plasma and serum and monkey serum. The antiserum was used to :1. demonstrate the presence of factor X precursor in blood from patients under anticoagulant therapy,2.
H, Prydz, A, Gladhaug
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SummaryA monospecific antiserum against factor X was prepared in rabbits. The antiserum precipitated factor X in human plasma and serum and monkey serum. The antiserum was used to :1. demonstrate the presence of factor X precursor in blood from patients under anticoagulant therapy,2.
H, Prydz, A, Gladhaug
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Thrombosis and Haemostasis, 1965
Summary1. Methods have been developed for the preparation of factor VII free of prothrombin and factor X, and of factor X with only a very low contamination with factor VII.2. Factors VII and X could be found with one stage methods in purified prothrombin prepared according to Seegers.3. Purified prothrombin was chromatographed on DE AE-cellulose.
K, LECHNER, E, DEUTSCH
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Summary1. Methods have been developed for the preparation of factor VII free of prothrombin and factor X, and of factor X with only a very low contamination with factor VII.2. Factors VII and X could be found with one stage methods in purified prothrombin prepared according to Seegers.3. Purified prothrombin was chromatographed on DE AE-cellulose.
K, LECHNER, E, DEUTSCH
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The Factor‐X Defect: Recognition of Abnormal Forms of Factor X
British Journal of Haematology, 1970Summary. Six patients with the ‘Factor‐X defect’ have been investigated. At least five different forms of the defect were recognized by the use of the following laboratory tests: the kaolin cephalin clotting time as a measure of intrinsic clotting, the factor‐X assay employing either brain extract or Russell's viper venom, and the neutralization of a ...
K W, Denson +3 more
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Abnormal Factor X (Factor X Friuli) Coagulation Disorder
Acta Haematologica, 2009A new case with the abnormal factor X (factor X Friuli) coagulation disorder is presented: a 32-year- old female who was born outside Friuli and who complained of a bleeding tendency since childhood. The main laboratory features are prolonged prothrombin time, prolonged partial thromboplastin time, abnormal thromboplastm generation and normal Stypven ...
A, Girolami +3 more
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One Missense Mutation in the Factor X Gene Causing Factor X Deficiency—Factor X Kanazawa
International Journal of Hematology, 2001We investigated the molecular basis of factor X deficiency in a Japanese patient whose factor X activity and antigen level were 45% and 50% of normal control values, respectively. All exons and intron/exon junctions of the factor X gene were studied using a strategy combining polymerase chain reaction (PCR) amplification and nonradioactive single ...
E, Morishita +8 more
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Assessment of Factor VII and Factor X
Thrombosis and Haemostasis, 1966SummaryA method is described to separate factor VII from factor X in normal serum using electrophoresis in a polyvinyl chloride block. A potent source of factor X is obtained. This may be used in correction studies and for assessment of deficiencies of factor VII in patients.
S, Shaw +3 more
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