Results 101 to 110 of about 1,008,107 (310)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

DUA KASUS ACQUIRED PROTHROMBIN COMPLEX DEFICIENCY DENGAN PERDARAHAN INTRAKRANIAL : LAPORAN KASUS

JKS (Jurnal Kedokteran Syiah Kuala), 2017
Abstrak. Acquired Prothrombin Complex Deficiency (APCD) merupakan perdarahan spontan yang disebabkan oleh penurunan aktivitas faktor koagulasi yang tergantung vitamin K (faktor II, VII, IX dan X), sedangkan aktivitas faktor koagulasi lain, kadar ...
Jufitriani Ismy
doaj   +1 more source

Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis

Case Reports in Hematology, 2023
Acquired coagulopathies resulting from factor X deficiency are rare and typically associated with amyloidosis or plasma cell dyscrasia. Factor X plays a pivotal role in the coagulation cascade, converting prothrombin into thrombin and facilitating the ...
P. Rossignon, F. Grandjean, A. Claessens, N. Weynants   +3 more
doaj   +1 more source

Suppressing CMB low multipoles with ISW effect

, 2013
Recent results of Planck data reveal that the power in the low multipoles of the CMB angular power spectrum, approximately up to $l=30$, is significantly lower than the theoretically predicted in the best fit $\Lambda$CDM model.
Das, Santanu, Souradeep, Tarun
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Review Dental Treatment of Patients with Congenital Bleeding Disorders

Česká Stomatologie a Praktické Zubní Lékařství, 2014
Objectives: The commonest congenital bleeding disorders in childhood are hemophilia, von Willebrand disease and deficiency of factor XI. Disease is characterized by a deficient of coagulability. It is a gonosomal recessive condition.
J. Papež, K. Chleborád, T. Dostálová
doaj   +1 more source

What Immunological Defects Predispose to Non-tuberculosis Mycobacterial Infections? [PDF]

, 2017
Nontuberculous mycobacteria (NTM) are categorized as one of the large and diverse groups of environmental organisms which are abundant in water and soil.  NTM cause a variety of diseases in humans that mainly affect the lung.
Adcock, IM, Garssen, J, Kazempour Dizagie, M, Mirsaeidi, M, Moloudizargari, M, Mortaz, E, Movassaghi, M, Varahram, M   +7 more
core  

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency [PDF]

, 2017
Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by
Atkin, S. L., Atkin, Stephen, Clark, AL, Clark, Andrew, Gonzalez, S., Gonzalez, Susana, Javed, Z., Javed, Zeeshan, Sathyapalan, T., Sathyapalan, Thozhukat, Windram, Hull, Windram, J. D.   +11 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Factor X Concentrate Treatment Schedule and Dosing in Acquired FX Deficiency

Hematology Reports
Background: Acquired factor X (FX) deficiency is a rare condition that can cause life threatening bleeding. Here we outline a successful management strategy for gastrointestinal bleeding (GI) using human FX concentrate.
Andrew Ross, Rebecca J. Shaw, Louise Garth, Cathy Farrelly   +3 more
doaj   +1 more source