Results 121 to 130 of about 1,584,900 (350)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Diagnosis, therapeutic advances, and key recommendations for the management of factor X deficiency.

Blood reviews, 2021
F. Peyvandi, G. Auerswald, S. Austin, R. Liesner, K. Kavaklı, M. Á. Álvarez Román, C. Millar   +6 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Molecular gas in late-type galaxies

, 2001
We present $^{12}$CO(J=1--0) line observations of 22 low-luminosity spiral galaxies in the Virgo cluster. These data, together with 244 others available in the literature, allow us to build a large sample that we use to study the molecular gas properties
A. Boselli, Allen, Allen, Alton, Alton, Arimoto, Bianchi, Bicay, Binggeli, Binggeli, Boissier, Bolatto, Boselli, Boselli, Boselli, Boselli, Boselli, Boselli, Boselli, Bouchet, Casoli, Casoli, Cayatte, Contursi, Devereux, Devereux, Devereux, G. Gavazzi, Gavazzi, Gavazzi, Gavazzi, Gavazzi, Gavazzi, Gavazzi, Gavazzi, Gavazzi, Guélin, Guélin, Haynes, Haynes, Helou, Hoffman, Hoffman, Hoffman, Hoopes, Hunter, Hunter, Israel, J. Lequeux, Kaufman, Kenney, Kenney, Kenney, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kennicutt, Kobulnicky, Koornneef, Lequeux, Magri, Moss, Neininger, Polk, Rand, Rubio, Rubio, Sage, Schmidt, Schneider, Scodeggio, Sodroski, Strong, Taylor, Taylor, Thuan, van den Bergh, Walterbos, Wild, Wilson, Young, Young, Young, Zaritsky   +86 more
core   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Ram pressure stripping and galaxy orbits: The case of the Virgo cluster

, 2001
We investigate the role of ram pressure stripping in the Virgo cluster using N-body simulations. Radial orbits within the Virgo cluster's gravitational potential are modeled and analyzed with respect to ram pressure stripping.
Allen C., B. Vollmer, Boselli A., C. Balkowski, Cavaliere A., Chamaraux P., Combes F., Giraud E., Guiderdoni B., Knude J., Schindler S., Takeda H., V. Cayatte, Vollmer B., W. J. Duschl, Warmels R. H.   +15 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

PERAWATAN GIGI DAN MULUT PENDERITA HEMOFILIA

Journal of Dentistry Indonesia, 2015
Haemophilia is a congenital haemorrhagic disorders passed down by the x linked recessive, divided into two: Haemophilia A caused by deficiency of factor VIII and Haemophilia B caused by deficiency of factor IX.
Siti Marhamah
doaj   +1 more source

Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy. [PDF]

, 2002
BackgroundIron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous norepinephrine would alter heart rate (HR) and contractility, 2) abdominal aorta would be larger ...
Chew, Herbert George, Gibbs, Brett Jason, Hearthway, Megan Lesley, Motsko, Madelyne, Mullendore, Michael Eugene, Premo, Daniel Aaron, Sappington, Andrea, Turner, Lexa Rae, Walker, LeeAnn   +8 more
core   +1 more source