Results 281 to 290 of about 15,654,533 (356)

Spanish Translated Abstracts. [PDF]

PM R
europepmc   +1 more source

[Effect of Vimala infant massage on mothers with postpartum depression]. [PDF]

Rev Med Inst Mex Seguro Soc
González AP, Reyes-Méndez MA, Paque-Bautista C, Rodríguez-Ramírez FJ, Sosa-Bustamante GP.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

[Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context]. [PDF]

Rev Med Inst Mex Seguro Soc
Gallardo-Hernández CA, Díaz-Alberto J, Palma-Jacinto JA, Montero-Ruíz O, Ramírez-Franco U.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Linking maternal childhood maltreatment to health-related and psychosocial risk factors during pregnancy: intergenerational implications for early child development. [PDF]

Eur J Psychotraumatol
Reyentanz E, Gerlach J, Eichler A, Vasileva M, Golub Y.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

[Social pain: a clinically relevant literature review in primary care]. [PDF]

Aten Primaria
Ordóñez Azuara YG, Gutiérrez Herrera RF, Hernandez González R, Jasso Castillo MG.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

[Risk factors associated with inadequacy of empirical treatment in patients with sepsis and bacteremia attended in an emergency department]. [PDF]

Rev Esp Quimioter
Motos-Bescós M, Ruiz-Ramos J, Agra-Montava I, Moliné-Pareja A, Palacio-Alvarez P, Villarejo-Jiménez A, Pomar-Solchaga V.   +6 more
europepmc   +1 more source