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Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1234-1247, November 2026.In this nationwide ENEIDA registry study, anti‐TNF therapy after prior exposure to a different biologic mechanism of action showed reduced treatment durability in inflammatory bowel disease, with a particularly marked impact in ulcerative colitis, where short‐ and long‐term clinical effectiveness was also lower. ABSTRACT Background The expanding use of
Carmen Yagüe Caballero +85 more
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Alimentary Pharmacology &Therapeutics, Volume 64, Issue 10, Page 1432-1447, November 2026.The HLA‐A*11:01 allele is associated with persistent viraemia and advanced liver fibrosis in HDV infection. HLA‐A*11:01 carriers exhibit a reduced T‐cell repertoire, suggesting a narrower T‐cell response to the infection. ABSTRACT Background Hepatitis delta virus (HDV) infection causes the most severe form of viral hepatitis, with highly heterogeneous ...
Maria Francesca Cortese +11 more
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Brain Pathology, Volume 36, Issue 6, November 2026.Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
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Surviving Males With PORCN Variants: Expanding the Clinical, Molecular, and Mechanistic Spectrum
Clinical Genetics, Volume 110, Issue 5, Page 605-615, November 2026.Pathogenic PORCN variants are compatible with male survival in both mosaic and non‐mosaic states, expanding the FDH/PONGOS spectrum and improving diagnosis and genetic counseling. ABSTRACT Pathogenic variants in PORCN cause focal dermal hypoplasia (FDH/Goltz syndrome), an X‐linked dominant disorder historically considered lethal in males, with milder ...
Lucía Miranda‐Alcaraz +23 more
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Os factores de competitividade e a competitividade de um território
1998Povos e Culturas, v. 6 (1998): Lisboa: contemporaneidade e futuro.
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Gestión de diseño y desarrollo de producto, factores de competitividad nacional
Revista Clepsidra, 2008 En un entorno globalizado y dinámico, aspectos como la gestión de diseño y el desarrollo de producto adquieren protagonismo e importancia en la construcción de plataformas competitivas. El producto se convierte en un factor diferenciador y articulador de las estrategias empresariales en mercados altamente ...
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Factores de competitividad de la industria láctea
Para la economía de los países del mundo, la importancia del sector lácteo muestra escalas, pero su relevancia es clara al ser un factor de producción y productividad clave en el ámbito internacional, debido a que la producción de leche y sus derivados se constituye en un aspecto esencial para la nutrición mundial, generando empleos, impulsando el ...Daniel Humberto Narvaez Gallardo +6 more
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