Results 241 to 250 of about 951,451 (326)

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

Contrast analysis for competing hypotheses: A tutorial using the R package cofad. [PDF]

Behav Res Methods
Henninger M, Malejka S, Titz J.
europepmc   +1 more source

Covariate adjustment, factorial designs and clustered data in diagnostic accuracy studies

Weber, Philipp, Vogel, Frederike, Konietschke, Frank, Zapf, Antonia   +3 more
openalex   +1 more source

Analysis of a Modified Version of the Inventory of Non‐Ataxia Signs Over 12 Years in Patients with Friedreich's Ataxia in the EFACTS Study

Movement Disorders, EarlyView.
Abstract Background Friedreich's ataxia is a rare, neurodegenerative, multisystem disorder. While ataxia is a hallmark, non‐ataxia signs, including muscle weakness, spasticity, and dysphagia are equally disabling. The Inventory of Non‐Ataxia Signs (INAS) is a symptom list transformable to a 16‐item count.
Stella Andrea Lischewski, Imis Dogan, Paola Giunti, Michael H. Parkinson, Caterina Mariotti, Alexandra Durr, Claire Ewenczyk, Sylvia Boesch, Wolfgang Nachbauer, Thomas Klopstock, Claudia Stendel, Francisco Javier Rodríguez de Rivera Garrido, Ludger Schöls, Zofia Fleszar, Thomas Klockgether, Marcus Grobe‐Einsler, Ilaria Giordano, Myriam Rai, Massimo Pandolfo, Heike Jacobi, Ralf‐Dieter Hilgers, Jörg B. Schulz, Kathrin Reetz, on behalf of the EFACTS Study Group   +23 more
wiley   +1 more source

Production of <i>Dichostereum sordulentum</i> Laccase and Its Entrapment in Lignocellulosic Biopolymers for Estrogen Biodegradation. [PDF]

Molecules
Vázquez V, Botto E, Bertone A, Turull M, Santos LHMLM, Giorgi V, Bonfiglio F, García-Alonso J, Menéndez P, Ovsejevi K, Gioia L.   +10 more
europepmc   +1 more source

The impact of recent approvals on future alzheimer's disease clinical development: Statistical considerations for combination trials. [PDF]

J Prev Alzheimers Dis
Dickson SP, Mallinckrodt C, Burstein AH, Nisenbaum L, Fillit HM, Zhang C, Hendrix SB.   +6 more
europepmc   +1 more source

Optimal hierarchial factorial designs : the multiple design multiresponse case with cost constraint

, 1973
Samuel V. Givens
openalex   +1 more source

Advancing Severe Plastic Deformation for Tubular Samples: Systematic Review and Machine Learning Optimization

MetalMat, EarlyView.
This review highlights recent advancements in Severe Plastic Deformation (SPD) techniques tailored for tubular samples. The mechanisms of processing are critically discussed with emphasis on microstructural control and the governing process parameters that enable refinement to ultrafine‐ and nano‐grained structures. Comparative insights into equivalent
Eman M. Zayed, Abdulrahman I. Alateyah, Waleed H. El‐Garaihy, Mahmoud Shaban, Majed Alinizzi, Nahed A. El‐Mahallawy   +5 more
wiley   +1 more source

Reconsidering Volume‐Based Drug Procurement Policy: The Consequences of Manufacturers' Optimal Production Planning and Breach Strategies

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This paper examines the impacts of Volume‐Based Procurement (VBP) policies on pharmaceutical supply chains, with a focus on the strategic behaviors of manufacturers. VBP aims to reduce costs and stabilize supplies by centralizing procurement through competition based on volumes and prices.
Nani Zhou, Tong Wang, Guohua Wan
wiley   +1 more source

MASHt: Software for statistical analysis of transcriptomes' qualitative features in factorial experiments. [PDF]

Bioinformation
Nuc M, Stanoch M, Cwiek-Kupczynska H, Naganowska B, Krajewski P.   +4 more
europepmc   +1 more source