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Preparation and optimization of PIT solid lipid nanoparticles via statistical factorial design

European Journal of Medicinal Chemistry, 2012
The objective of this study was the preparation, physico-chemical characterization and statistical optimization of cationic solid lipid nanoparticles (SLN) prepared by the PIT method as potential carrier for gene therapy, emphasizing the application of factorial design in such a kind of studies.
CARBONE, CLAUDIA   +4 more
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Parametric statistics and levels of measurement: Factorial designs and multiple regression.

Psychological Bulletin, 1990
Let Y be a continuous, ordinal measure of a latent variable θ. In general, for factorial designs, an analysis of variance of the observed variable Y cannot be used to draw inferences about main effects and interactions on the latent variable θ even when the standard normality and equality of variance assumptions hold.
Mark L. Davison, Anu R. Sharma
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Statistical Analysis of Factorial Diallel Design over Environments

Biometrical Journal, 1987
AbstractStarting from the experimental situation that in each of a environments all mp combinations between m maternal and p paternal genotypes are raised in b replications (blocks), a linear model is formulated for a quantitative character. On the basis of this model formulae for the analysis of variance are given.
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A STATISTICAL ANALYSIS OF FRACTIONAL FACTORIAL DESIGN USING A FUZZY PROBABILISTIC APPROACH

2023
In factorial experiments, treatment combinations increase as the number of factors increases. While handling a large number of factors, many difficulties are encountered. Moreover, mechanical errors like mistaken identification of plots, wrong labeling of treatments, etc., may creep in.
Sri Devi, P., Pachamuthu, M.
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Sulfate removal from mine-impacted water by electrocoagulation: statistical study, factorial design, and kinetics

Environmental Science and Pollution Research, 2020
This work aimed to remove sulfate and acidity from mine-impacted water (MIW) via electrocoagulation (EC), a technique which stands as an advanced alternative to chemical coagulation in pollutant removal from wastewaters. The multiple electrochemical reactions occurring in the aluminum anode and the stainless steel cathode surfaces can form unstable ...
Caroline Rodrigues   +5 more
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Statistical robust technique procedures for fractional factorial design with non constant variance

AIP Conference Proceedings, 2017
Fractional factorial design (FFD) has been widely used in engineering, agricultural, biology and social sciences. Although FFD is considered a conventional design, there still occurs a basic problem such as nonconstant variance may affect parameter estimation.
Nadia Mohd Yunus, Nora Muda
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Statistical approaches in toxicology: The use of factorial designs and multivariate methods

Medical Informatics, 1985
(1985). Statistical approaches in toxicology: The use of factorial designs and multivariate methods. Medical Informatics: Vol. 10, No. 2, pp. 143-151.
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Design and statistical analysis of confounded factorial experiments

2018
Ten confounded factorial experiments were designed with the purpose of filling in the existing gaps among the available plans. The method of analyzing such experiments was presented and illustrated by the 5 x 2 x 2 experiment. For each design, the reasons why a particular plan was adopted were discussed; the instructions for computing the sums of ...
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Development of nifedipine-loaded albumin microspheres using a statistical factorial design

International Journal of Pharmaceutics, 1996
Nifedipine-loaded albumin microspheres were prepared by a chemical cross-linking method to develop a sustained-release form. The qualities of the nifedipine-loaded albumin microsphere products were affected by several variables. In this study, the effects on the percentage of nifedipine incorporated into albumin microspheres of four different variables
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FULL FACTORIAL DESIGN VERSUS CENTRAL COMPOSITE DESIGN: STATISTICAL COMPARISON AND IMPLICATIONS FOR SPRAY DROPLET DEPOSITION EXPERIMENTS

Transactions of the ASAE, 1999
The optimization of spraying parameters to improve pesticide efficacy and reduce environmental impacts requires a large number of experimental treatments. Some experimental designs can be used to reduce the required number of treatment combinations. A comparison between a 33 factorial design and a central composite design (CCD) regarding the model ...
null B. Panneton   +4 more
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