Results 221 to 230 of about 295,217 (268)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Machine learning models for drug-drug interaction prediction from computational discovery to clinical application. [PDF]

NPJ Digit Med
Lu Y, Chen J, Fan N, Song W, Sheng H, Yang Y, Wang J.   +6 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Assessing spatial variability and source identification of heavy metals in agricultural soils: A geostatistical and multivariate analysis of coastal eastern Zhejiang, China. [PDF]

PLoS One
Ji J, Wu X.
europepmc   +1 more source

Viral epidemic potential is not uniformly distributed across the bat phylogeny. [PDF]

Commun Biol
Cummings CA, Vicente-Santos A, Carlson CJ, Becker DJ.   +3 more
europepmc   +1 more source

scIRT: Imputation and Dimensionality Reduction for Single-Cell RNA-Seq Data by Combining NMF with SMOTE. [PDF]

Int J Mol Sci
Mou Y, Li S, Ji G.
europepmc   +1 more source

Correction: Nonnegative matrix factorization for analyzing state dependent neuronal network dynamics in calcium recordings. [PDF]

Sci Rep
Carbonero D, Noueihed J, Kramer MA, White JA.   +3 more
europepmc   +1 more source

Interleaving cortex-analog mixing improves deep non-negative matrix factorization networks. [PDF]

Front Comput Neurosci
Nouri M, Rotermund D, Garcia-Ortiz A, Pawelzik KR.   +3 more
europepmc   +1 more source

LONMF: a non-negative matrix factorization model based on graph Laplacian and optimal transmission for paired single-cell multi-omics data integration. [PDF]

BMC Bioinformatics
Nan M, Ren Q, Fu Y, Chen X, Qi G, Wang L, Gao J.   +6 more
europepmc   +1 more source