Results 281 to 290 of about 406,461 (313)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Machine learning of time series data using persistent homology. [PDF]

Sci Rep
Ichinomiya T.
europepmc   +1 more source

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Hyperspectral remote sensing image destriping via spectral-spatial factorization. [PDF]

Sci Rep
Zhan Y, Yu Q, Liu J, Wang Z, Yang Z.
europepmc   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Joint embedding-classifier learning for interpretable collaborative filtering. [PDF]

BMC Bioinformatics
Réda C, Vie JJ, Wolkenhauer O.
europepmc   +1 more source

Conic curve encryption and digital signature based on complex number theory for cybersecurity applications. [PDF]

Sci Rep
Kamal A, El-Kamchochi HA, El-Fahar A, Hagras EAA.   +3 more
europepmc   +1 more source

Low power IoT device communication through hybrid AES-RSA encryption in MRA mode. [PDF]

Sci Rep
Chang Q, Ma T, Yang W.
europepmc   +1 more source

Adaptive clustering for medical image analysis using the improved separation index. [PDF]

Sci Rep
Jahanian M, Karimi A, Eraghi NO, Zarafshan F.   +3 more
europepmc   +1 more source