Results 151 to 160 of about 6,109,051 (355)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
SchizophreniaCognitive deficits in schizophrenia significantly hinder functional outcomes and often remain unresponsive to conventional treatments. While initial evidence suggested potential pro-cognitive effects of electrical brain stimulation in schizophrenia ...
Eisa Jafari +8 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Factors which influence the behavior of turbofan forced mixer nozzles [PDF]
A finite difference procedure was used to compute the mixing for three experimentally tested mixer geometries. Good agreement was obtained between analysis and experiment when the mechanisms responsible for secondary flow generation were properly modeled.
Anderson, B. H., Povinelli, L. A.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Patient Preference and AdherenceXinyi Hao,1 Aiping Wang2 1Nursing Department, Peking Union Medical College Hospital, Peking, 100730, People’s Republic of China; 2Nursing College, The China Medical University, Shenyang, 110122, People’s Republic of ChinaCorrespondence: Aiping Wang ...
Hao X, Wang A
doaj
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Patient Preference and AdherenceZhu Han, Li Wang School of Nursing, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, People’s Republic of ChinaCorrespondence: Li Wang, School of Nursing, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning ...
Han Z, Wang L
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