Results 51 to 60 of about 1,255,893 (247)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Faculty Members’ Promotion: Challenges and Solutions [PDF]

Strides in Development of Medical Education, 2021
Sara Shafian, Mahla Salajegheh
doaj   +1 more source

New tools for systematic evaluation of teaching qualities of medical faculty: results of an ongoing multi-center survey.

PLoS ONE, 2011
BackgroundTools for the evaluation, improvement and promotion of the teaching excellence of faculty remain elusive in residency settings. This study investigates (i) the reliability and validity of the data yielded by using two new instruments for ...
Onyebuchi A Arah, Joost B L Hoekstra, Albert P Bos, Kiki M J M H Lombarts   +3 more
doaj   +1 more source

Correction to: Effects of Low-Frequency Electromagnetic Fields on the Histopathology of Liver Tissues in Rat Offspring [PDF]

Journal of Mazandaran University of Medical Sciences, 2023
Correction to: Effects of Low-Frequency Electromagnetic Fields on the Histopathology of Liver Tissues in Rat Offspring Mohammad Hassan Kalantar Neyestanaki1, Homa Soleimani2, Sahar Ghaffari Khaligh3, Parvindokht Bayat4 1 Medical Doctor, Faculty of ...
Mohammad Hassan Kalantar Neyestanaki, Homa Soleimani, Sahar Ghaffari Khaligh, Parvindokht Bayat   +3 more
doaj  

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Mentoring Matters: Faculty's Role in Developing Competent Doctors

GAIMS Journal of Medical Sciences
The integration of structured mentoring programs within the medical curriculum and the inclusion of mentoring sessions in faculty development programs represent a forward-thinking approach by the NMC.
Mandar Chandrachood
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Faculty Development in Medical Education

Journal of Chittagong Medical College Teachers' Association, 2016
Faculty refers to those who teachers. It is defined as group of body of peoples, specially teachers, professors and lecturers with a common duty or obligation which is to teach at a certain educational institution. They are the academic staff of the institution and also called the teaching staff.
Md Mokhles Uddin, Sazzad Mohammad Yusuff, Tapash Mitra, Abdul Awal, Ali Asgar Chowdhury   +4 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source