Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Prof. dr. ing. Rostislav Bereziuc, Doctor Honoris Causa al Universităţii „Ştefan cel Mare” Suceava [Prof. dr. Rostislav Bereziuc, Doctor Honoris Causa of University „Ştefan cel Mare” Suceava] [PDF]
Forestry Faculty
doaj
The Journey Between There and Here: Stories of a Faculty Writing Group [PDF]
Cecile Badenhorst +7 more
openalex
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Towards Establishing a Training Program to Support Future CS Teaching-focused Faculty [PDF]
Mohammed F. Farghally +2 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Stop the Snobbery! Why You’re Wrong About Community Colleges and Don’t Even Know It
Several weeks ago I attended my first community college commencement. Despite my staff status, I was pleased to be invited to sit among the faculty behind the stage.
Kim Leeder
doaj
The Influence of Vision, Mission, And Values Statement on Performance the Organization of Economic Education Study Program Faculty of Teacher Training and Education Science [PDF]
Witarsa Witarsa
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source

