Results 51 to 60 of about 5,494,201 (309)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Exploring predictors of social well-being of university teachers and students during the transition to online learning in a multicultural environment

Cogent Education
The COVID-19 pandemic has caused a sudden and universal shift towards online learning. This has led to a 'forced readiness’ for online education. Although some countries have eased restrictions, online education is becoming the new normal.
Negmeldin Alsheikh, Maxwell Peprah Opoku, Najwa Alhosani, Rachel Takriti, Noof Aljenebi, Hala Elhoweris, Rhoda Myra Garces-Bacsal   +6 more
doaj   +1 more source

Developing the HEART framework: a qualitative study on faculty engagement in service-learning in Malaysia [PDF]

Korean Journal of Medical Education
Purpose Most research on service-learning in health professions education has concentrated on student experiences, with little emphasis on staff engagement.
Chew-Fei Sow, Lay Khim Goh, Pek Sam Chong   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Faculty perceptions and conveyance of academic ethics to students in distance learning [PDF]

Proceedings of the Estonian Academy of Sciences
Emphasising academic ethics throughout the educational process is crucial for all learners. The applied research project at Tallinn Health University of Applied Sciences, titled Ê»Academic ethics as lecturer’s toolkit in the teaching process â ...
Maigi Lepik, Kateriina Rannula, Liina Männiksaar   +2 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

大學教師學術發表影響力之影響因素 Factors Influencing Publication Impact of Faculty

Journal of Research in Education Sciences
學術論文發表與被引用次數是高等教育評估大學教師研究影響力的主要測量指標，常被視為教育政策擬定、大學重要決策與資源分配的參照值。目前學術發表影響力之相關研究大多以書目學或引文計量為主，本研究目的有二：一為從學院、系所、個人三個層次，考驗學院領域、系所生師比、個人學術年資、指導研究生畢業人數、職等、國內（或國外）博士學位，以及性別等社會因素與大學教師學術發表影響力的關係；二為考量教育資料之階層結構，應用廣義線性混合效果模型樹分析具有巢套和群集特性之數據，進而釐清各因素與大學教師學術影響力之影響效果 ...
郭玲玲 Ling-Ling Kueh, 許清芳 Ching-Fan Sheu   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source