Results 91 to 100 of about 136,383 (292)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Full-Rate, Full-Diversity Adaptive Space Time Block Coding for Transmission over Rayleigh Fading Channels

, 2005
A full-rate, full-diversity Adaptive Space Time Block Coding (ASTBC) scheme based on Singular Value Decomposition (SVD) is proposed for transmission over Rayleigh fading channels.
Ng, S.X., Yeap, B.L., Hanzo, L.
core   +1 more source

Multipath and Doppler Characterization of an Electromagnetic Environment by Massive MDT Measurements From 3G and 4G Mobile Terminals

IEEE Access, 2019
This paper describes an innovative approach to radio channel characterization in UMTS and LTE mobile networks. In place of traditional drive tests (DT), which employ a single test mobile, a massive collection of georeferenced radio measurements is made ...
Andrea Scaloni, Pasquale Cirella, Mauro Sgheiz, Riccardo Diamanti, Davide Micheli   +4 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Fading Characteristics in Evaporation Duct: Fade Margin for a Wireless Link in the South China Sea

IEEE Access, 2018
Evaporation ducts (ED), which are caused by a rapid decrease in the refractive index of the lower atmosphere, are known to trap radio waves between the evaporation duct layer and the sea surface. Although signal propagation and refractivity estimation in
Khurram Shabih Zaidi, Varun Jeoti, Micheal Drieberg, Azlan Awang, Asif Iqbal   +4 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Environmental dosimetry in northwest Patagonia using LiF:Mg,Cu,P: Analysis of reproducibility, sensitivity, and fading changes over time

Radiation Protection and Environment
The environmental radiation dose depends on many factors, which have to be taken into account when monitoring programs are implemented. The aim of this study was to analyze the fading, reproducibility, and sensitivity changes over time in LiF:Mg,Cu,P ...
Pablo Andres
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source