Results 231 to 240 of about 89,107 (340)

Occurrence, Risk Factors, and Prognosis of Acute Cerebral Microinfarcts in CADASIL

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic cerebral small vessel disease in adults. This study investigates the occurrence, risk factors, and prognosis of acute cerebral microinfarcts (ACMIs) in patients with CADASIL.
Xuejiao Men   +11 more
wiley   +1 more source

Stochastic reservoir computers. [PDF]

open access: yesNat Commun
Ehlers PJ, Nurdin HI, Soh D.
europepmc   +1 more source

Association of Changes in Hand Pain With BMI, Employment, and Mental Well‐Being Over Four Years in Patients With Hand Osteoarthritis

open access: yesArthritis Care &Research, EarlyView.
Objective We aimed to characterize patients with hand osteoarthritis (OA) with deteriorating or improving hand pain and to investigate patients achieving good clinical outcome after four years. Methods We used four‐year annual Australian/Canadian Hand Osteoarthritis Index (AUSCAN) pain subscale (range 0–20) measurements from the Hand OSTeoArthritis in ...
Coen van der Meulen   +5 more
wiley   +1 more source

Random Learning Leads to Faster Convergence in ‘Model‐Free’ ILC: With Application to MIMO Feedforward in Industrial Printing

open access: yesInternational Journal of Adaptive Control and Signal Processing, EarlyView.
The cost as a function of the number of experiments for a non‐symmetric 21×21$$ 21\times 21 $$ system. Four approaches are shown: the proposed stochastic conjugate gradient ILC (SCGILC) method (), deterministic conjugate gradient ILC (), stochastic gradient descent ILC () and deterministic gradient descent ILC ().
Leontine Aarnoudse, Tom Oomen
wiley   +1 more source

Activation of SIRT1 Reduces Renal Tubular Epithelial Cells Fibrosis in Hypoxia Through SIRT1‐FoxO1‐FoxO3‐Autophagy Pathway

open access: yesAdvanced Biology, EarlyView.
Hypoxia promotes the epithelial‐mesenchymal transition (EMT) of renal tubular epithelial cells via the SIRT1‐FoxO1‐FoxO3‐autophagy pathway, thereby resulting in the fibrosis of renal tubular epithelial cells. Activation of SIRT1 or induction of autophagy inhibits this process, alleviating hypoxia‐induced fibrosis.
Guangyu Wang   +6 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

open access: yesAdvanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi   +4 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

open access: yesAdvanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang   +5 more
wiley   +1 more source

Development and Validation of a One‐Dimensional Finite Difference Simulation Scheme for Polymer Laser Powder Bed Fusion with Application to the Effect of the Inter Layer Time

open access: yesAdvanced Engineering Materials, EarlyView.
The study presents an efficient simulation approach for the polymer laser powder bed fusion process polymers process, validated with polyamide 12, polyamide 6, and polyetherketoneketone. It shows that inter layer time affects part density, with 90s yielding dense parts.
Claas Bierwisch   +4 more
wiley   +1 more source

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