Results 11 to 20 of about 11,498,837 (391)

The role of RIPK1 mediated cell death in acute on chronic liver failure

Cell Death and Disease, 2021
Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated ...
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan   +13 more
doaj   +1 more source

Moderate Aortic Stenosis in Patients With Heart Failure

Korean Circulation Journal, 2022
Author's summary Moderate aortic stenosis with concomitant heart failure portends a significantly worse prognosis in both preserved and reduced left ventricular ejection fraction.
V. Truong, John Ernst, Akhil Pallerla, Amitesh Verma, C. Bartone, C. Palmer, E. Chung   +6 more
semanticscholar   +1 more source

The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment

Journal of Immunology Research, 2022
Diabetes and cancer are common diseases and are frequently diagnosed in the same individual. These patients need to take antidiabetic drugs while receiving antitumor drugs therapy. Recently, immunotherapy offers significant advances for cancer treatment.
Ze-Tao Zhan, Lu Liu, Ming-Zhen Cheng, Yi Gao, Wei-Jie Zhou   +4 more
doaj   +1 more source

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.

New England Journal of Medicine, 2019
BACKGROUND In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of
J. McMurray, S. Solomon, S. Inzucchi, L. Køber, M. Kosiborod, F. Martinez, P. Ponikowski, M. Sabatine, I. Anand, J. Bělohlávek, M. Böhm, C. Chiang, V. Chopra, Rudolf A. de Boer, Akshay S. Desai, M. Diez, J. Drożdż, A. Dukát, J. Ge, J. Howlett, T. Katova, M. Kitakaze, C. Ljungman, B. Merkely, J. Nicolau, E. O’Meara, M. Petrie, P. N. Vinh, M. Schou, S. Tereshchenko, S. Verma, C. Held, D. DeMets, K. Docherty, P. Jhund, O. Bengtsson, M. Sjöstrand, A. Langkilde, Modele O Ogunniyi   +38 more
semanticscholar   +1 more source

Beta Blockers Up-Titration in Patients with Heart Failure Reduced Ejection Fraction and Cardiac Resynchronization Therapy, a Single Center Study

Medical Sciences, 2019
Clinical trials have shown the benefits of β-blockers therapy in patients with heart failure reduced ejection fraction. These benefits include improved survival and a reduced need for hospitalization. Cardiac resynchronization therapy has emerged as
Daniele Masarone, Marina Verrengia, Ernesto Ammendola, Rita Gravino, Fabio Valente, Rossella Vastarella, Marta Rubino, Giuseppe Limongelli, Giuseppe Pacileo   +8 more
doaj   +1 more source

Learning from failure [PDF]

, 2012
We study decentralized learning in organizations. Decentralization is captured through a symmetry constraint on agents’ strategies. Among such attainable strategies, we solve for optimal and equilibrium strategies. We model the organization as a repeated
Akerboom, B.M., Beek, J.J. van, Bloemenkamp, K.W., Groenewout, M., group, P.t., Haak, M.C., Ham, D.P. van der, Kars, M.E., Kuppens, S., Kwee, A., Mantel, G.D., Mol, B.W., Molkenboer, J.F., Moonen, R., Mulder, A.L., Nijhuis, J.G., Opmeer, B.C., Pampus, M.G. van, Pernet, P.J., Porath, M., Sikkema, M., Vijgen, S.M., Weinans, M.J., Wijngaarden, W.J. van, Wildschut, H.I.J., Willekes, C., Woiski, M.D.   +26 more
core   +9 more sources

Coagulation factor XIII activity predicts left ventricular remodelling after acute myocardial infarction

ESC Heart Failure, 2020
Aims Acute myocardial infarction (MI) is the major cause of chronic heart failure. The activity of blood coagulation factor XIII (FXIIIa) plays an important role in rodents as a healing factor after MI, whereas its role in healing and remodelling ...
Anna Frey, Tobias Gassenmaier, Ulrich Hofmann, Dominik Schmitt, Georg Fette, Almuth Marx, Sabine Herterich, Valérie Boivin‐Jahns, Georg Ertl, Thorsten Bley, Stefan Frantz, Roland Jahns, Stefan Störk   +12 more
doaj   +1 more source

Albumin Lipidomics Reveals Meaningful Compositional Changes in Advanced Cirrhosis and Its Potential to Promote Inflammation Resolution

Hepatology Communications, 2022
Albumin infusions are therapeutically used to revert hypoalbuminemia and to replace the extensively oxidized albumin molecule circulating in patients with acutely decompensated (AD) cirrhosis.
Mireia Casulleras, Roger Flores‐Costa, Marta Duran‐Güell, Ingrid W. Zhang, Cristina López‐Vicario, Anna Curto, Javier Fernández, Vicente Arroyo, Joan Clària   +8 more
doaj   +1 more source

Dramatic disease regression in a case of HFrEF with end‐stage renal failure treated with sacubitril/valsartan and SGLT2i

ESC Heart Failure, 2023
The amount of evidence for guideline‐directed new heart failure (HFrEF) disease‐modifying drugs in the context of chronic kidney disease (CKD) is relatively modest, especially in end‐stage CKD. We report a case of dramatic reverse remodelling and disease
Massimo Mapelli, Valentina Mantegazza, Cristina Ferrari, Roberto Cimino, Riccardo Maragna, Gianluca Pontone, Mauro Pepi, Piergiuseppe Agostoni   +7 more
doaj   +1 more source

Decline and repair, and covariate effects [PDF]

, 2015
The failure processes of repairable systems may be impacted by operational and environmental stress factors. To accommodate such factors, reliability can be modelled using a multiplicative intensity function.
Andersen, Dekker, Doyen, Guo, Han, Jiang, Kalbfleisch, Kijima, Kijima, Kirschenmann, Lam, Malik, Meyer, Nakagawa, Philip Scarf, Scarf, Shaomin Wu, Wang, Wu, Wu, Xiang, Zhong   +21 more
core   +3 more sources