Results 261 to 270 of about 11,498,837 (391)

Graft failure [PDF]

Bone Marrow Transplantation, 2020
openaire   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Unraveling the Impact of COVID-19 Lockdowns on Youth Sports and Physical Activity: Insights From a Retrospective Cohort Study in Italy

International Journal of Pediatrics
E. Lodi, P. A. Gasparini, A. Brusini, M. L. Poli, G. Savino, M. G. Modena   +5 more
doaj   +1 more source

Cardiac vagal activity is associated with insulin metabolism in heart failure: Results from the Myovasc study. [PDF]

Cardiovasc Diabetol
Bélanger N, Zeid S, Velmeden D, Schulz A, Koeck T, Rausch F, Fooß B, Kazemi-Asrar F, Lackner KJ, Gori T, Münzel T, Prochaska JH, Simon P, Wild PS.   +13 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Diastolic Dysfunction in Acute and Critical Illness: Acute Pathophysiology to Chronic Heart Failure. [PDF]

JACC Adv
Fisher T, Abbawy M, Holden F, Cotton J, Hothi S, Ingram T, Dhamodaran K, Thilak S, Chacko C, Gao-Smith F, Veenith T.   +10 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A lethal combination: fulminant liver failure due to <i>Babesia microti</i> and <i>Borrelia burgdorferi</i> co-infection. [PDF]

Ther Adv Infect Dis
Elalfy A, Grahovac D, Dumic I, Gavrancic T.   +3 more
europepmc   +1 more source

Glutathione-S-Transferase and Thiol Stress in patients with acute renal failure [PDF]

, 2010
Mungli Prakash, Vivekananda Kedage, Muttigi, K.S. Nataraj, W.W. Baig, RP Attur   +5 more
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