PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Damage and Failure Analysis of Polymer-Based Composites. [PDF]
Polymers (Basel)Cheng X, Huang W, Zhang Q.
europepmc +1 more source
Comparison of failure criteria application for fml buckling strength analysis. [PDF]
, 2015 Banat, D., Mania, Radosław J.
core
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Advancing real-time validation of automotive software systems via continuous integration and intelligent failure analysis. [PDF]
Sci RepAbboush M, Knieke C, Rausch A.
europepmc +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Trans-Scale Progressive Failure Analysis Methodology for Composite Materials Incorporating Interfacial Phase Effect. [PDF]
Materials (Basel)Li Z +5 more
europepmc +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
Crack Failure Analysis of Hot-Stamping Die Insert for Manufacturing an Automobile A-Pillar. [PDF]
Materials (Basel)Wang S +7 more
europepmc +1 more source