Results 151 to 160 of about 8,243,947 (299)

Damage-Failure Characteristics and Energy Evolution Laws of Reservoir Rock with Irregular Hydraulic Borehole under Uniaxial Compression. [PDF]

ACS Omega
Wang L, Xiao S, Ding J.
europepmc   +1 more source

Failing to Succeed: Success Through the Lens of Failure

, 2017
The capacity to learn is a core component of the human experience. Our unique learning process plays a key role in the success and longevity of our species. Failure is an integral part of that process.
De Freitas, Vincent
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

A combined experimental and DEM study on the mechanical and failure characteristics of fissured sandstone under complex stress conditions. [PDF]

Sci Rep
Liu S, Xie C, Wang R, Han S.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Dynamic behavior and failure characteristics of granite with different shapes of holes. [PDF]

Sci Rep
Liu H, Chen L, Ma K, Ren F.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Experimental study on the structural failure characteristics and load-bearing mechanism of anchored fractured rock mass. [PDF]

Sci Rep
Liu M, Li Z, Du F, Wang W, Zhai M, Shi J.   +5 more
europepmc   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Mechanical Response and Failure Characteristics of Granite Under In Situ High-Temperature and High-Pressure True Triaxial Conditions. [PDF]

Materials (Basel)
Ma Y, Fu X, Wu Y, Zhou C, Xue J, Zhang X, Yang J, Li S, Li X, Mao T, Hu Y, Diao Y, Sun X.   +12 more
europepmc   +1 more source