Results 181 to 190 of about 3,630,714 (312)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Experimental and numerical simulation studies on the mechanical properties and failure characteristics of rock masses with weak interlayers. [PDF]

PLoS One
Wang F, Yang Y, Wang Y, Li Z, Han B, Bin Y, Hu J, Yang Y, Xia Z.   +8 more
europepmc   +1 more source

Failure characteristics of rocks with non-persistent joints under local load. [PDF]

PLoS One, 2023
Cheng H, Zhao H.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Experimental Study on the Influence of Corrosion Duration on the Strength and Failure Characteristics of Sandstone. [PDF]

ACS Omega
Tang X, Li W, Wang R, Tao R, Li G.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Remote Monitoring of Patients with Heart Failure: Characteristics of Effective Programs and Implementation Strategies. [PDF]

Vasc Health Risk Manag
Teleanu IC, Bejan GC, Poiană IR, Mîrșu-Păun A, Dumitrescu SI, Stănescu AMA.   +5 more
europepmc   +1 more source

Experimental study on failure characteristics and rheological properties of pillar-like rock samples with different shapes. [PDF]

Sci Rep, 2023
Guo WB, Wang BB, Tan Y, Zhao GB, Bai EH, Guo MJ, Wen P, Ma ZB, Yang WQ, Wu DT.   +9 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Structural Behavior and Failure Characteristics of Fiber-Reinforced Polymer-Concrete Composite Beams Incorporating Glass Roving Tied GFRP Shear Connectors. [PDF]

Polymers (Basel)
Mehra AS, Singh SB, Kodur V.
europepmc   +1 more source