Results 71 to 80 of about 1,152,060 (219)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
ActuatorsThe development of unconventional and hybrid unoccupied aerial vehicles (UAVs) has gained significant momentum in recent years, with many designs utilizing small fans or rotary blades for vertical take-off and landing (VTOL). However, these systems often
Johnson Imumbhon Okoduwa +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Applied SciencesFiber-Reinforced Polymer (FRP)-laminated composite materials are increasingly recognized as a transformative solution for future structural applications, due to their exceptional properties, such as lightweight, superior fatigue life, corrosion ...
Muhammad Ali Sadiq, György Kovács
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Applied SciencesCellular structures are well-established in biological materials and are often mimicked in many kinds of structural designs applicable to engineering. This results from their lightweight designs and good mechanical properties.
Munashe Ignatius Chibinyani +3 more
doaj +1 more source
Mining-Induced Failure Criteria of Interactional Hard Roof Structures: A Case Study
Energies, 2019 Due to the additional abutment stress, interactional hard roof structures (IHRS) affect the normal operation of the coal production system in underground mining. The movement of IHRS may result in security problems, such as the failure of supporting body,
Wenlong Shen +5 more
doaj +1 more source
Review on the damage behavior of metal laminated composite
Materials Research Express, 2020 Metal laminated composite (MLC) have attracted widespread attention for their potential in achieving excellent properties. However, damage and failure are more likely to occur during the plastic deformation due to the existence of the interface region ...
Tao Huang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source