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Rifamycin antibiotics and the mechanisms of their failure
The Journal of Antibiotics, 2021Rifamycins are a class of antibiotics that were first discovered in 1957 and are known for their use in treating tuberculosis (TB). Rifamycins exhibit bactericidal activity against many Gram-positive and Gram-negative bacteria by inhibiting RNA polymerase (RNAP); however, resistance is prevalent and the mechanisms range from primary target modification
Rebekah A. Adams +9 more
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1971
The question of why the myocardium fails to contact normally and ultimately leads to congestive failure, has occupied the attention of both clinicians and basic scientists for decades. Nevertheless, it is only within recent years that improvements in clinical diagnostic techniques and development of more sophisticated physiological and biochemical ...
E H, Sonnenblick, E W, Gertz
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The question of why the myocardium fails to contact normally and ultimately leads to congestive failure, has occupied the attention of both clinicians and basic scientists for decades. Nevertheless, it is only within recent years that improvements in clinical diagnostic techniques and development of more sophisticated physiological and biochemical ...
E H, Sonnenblick, E W, Gertz
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International Test Conference, 2003. Proceedings. ITC 2003., 2004
MEMS components by their very nature have different and unique failure mechanisms than their macroscopic counterparts. This paper discusses failure mechanisms observed in various MEMS components and technologies. MEMS devices fabricated using bulk and surface micromachining process technologies are emphasized.
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MEMS components by their very nature have different and unique failure mechanisms than their macroscopic counterparts. This paper discusses failure mechanisms observed in various MEMS components and technologies. MEMS devices fabricated using bulk and surface micromachining process technologies are emphasized.
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Failure Modes and Mechanisms: Failure Modes and Mechanisms in MEMS
2010As defined in Chapter 2, reliability engineering is the process of analyzing the expected or actual failure modes of a product and identifying actions to reduce or mitigate their effect. A Failure Mode describes the way in which a product or process could potentially fail to perform its desired function and can be defined in several ways, of which the ...
Allyson L. Hartzell +2 more
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Mechanisms of Treatment Failure
1993The recently published overview of systemic treatment of patients with early breast cancer provides the best information available concerning the impact of these treatments on disease-free and overall survival [4] (reprinted in part in this volume). The modest reduction in risk of relapse achieved by these treatments may translate into major community ...
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Failure mechanisms in fibrous scaffolds
Acta Biomaterialia, 2013Polymeric fibrous scaffolds have been considered as replacements for load-bearing soft tissues, because of their ability to mimic the microstructure of natural tissues. Poor toughness of fibrous materials results in failure, which is an issue of importance to both engineering and medical practice.
C T, Koh +3 more
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2016
This chapter will review the concepts of fracture and fatigue that occupy most of part failures in mechanical system subjected to random stress (or loads). To figure out the mechanical system failures, it will benefit engineer to design the product structures—automobile, bridge, skyscrapers, and the others—in the allowable stress and strain as ...
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This chapter will review the concepts of fracture and fatigue that occupy most of part failures in mechanical system subjected to random stress (or loads). To figure out the mechanical system failures, it will benefit engineer to design the product structures—automobile, bridge, skyscrapers, and the others—in the allowable stress and strain as ...
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Illness: A mechanism for coping with failure
Social Science & Medicine (1967), 1973Abstract Illness represents one way of coping with failure and the physician plays a unique role as the sole authority granting legitimation for the sick role. For people of limited means or incomplete knowledge of and access to other medical alternatives, the neighborhood clinic, when it is free and accessible, may serve as the major locus for ...
Judith T. Shuval +2 more
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Mechanisms of Failure of Modular Prostheses
Clinical Orthopaedics and Related Research, 1992The expectations of wear and longevity of total hip components are based in large part on Charnley's early work. The evolution of the total hip from the one-piece, all-polyethylene acetabular component and fixed-head femoral component to the myriad of parts that comprise many of today's total hip designs has brought with it an array of potential ...
J P, Collier +6 more
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Time-To-Failure Models for Selected Failure Mechanisms in Mechanical Engineering
2010The mechanical properties of materials are related to the fundamental bonding strengths of the constituent atoms in the solid and any bonding defects which might form. A molecular model is presented so that primary bond formation mechanisms (ionic, covalent, and metallic) can be better understood.
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