Results 141 to 150 of about 5,959,491 (252)

Association between periodontitis and heart failure: Mechanisms and clinical implications (Review). [PDF]

Mol Med Rep
Zhang X, An X.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Repeated fatigue failure of shaft of cableway

, 1996
The shaft of the drive of a cable car failed after three years' service and was replaced by a newly designed one. This shaft again failed after three years. This second failure of the shaft was thoroughly analyzed and attributed to fretting fatigue.
Kieselbach, R. (author)
core   +1 more source

Failure Mechanisms in Off-Label Electrosurgery Devices for BASILICA, LAMPOON, and SESAME. [PDF]

JACC Cardiovasc Interv
Murray JL, Montes AR, Jaimes AE, Lederman RJ, Yildirim DK.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets. [PDF]

Cureus
Hussain T, Pandey A, Karki D, Neupane P.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Efferocytosis in heart failure: Mechanisms, dysregulation and therapeutic potential. [PDF]

Theranostics
Oviri O, Liu S, Huang H, Bai X, Yao J, Ding Z.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Pediatric dilated cardiomyopathy and the progression to heart failure: mechanisms and interventions focusing on the "gene-inflammation-metabolism" axis. [PDF]

Front Cardiovasc Med
Jiang J, Luo D, Gu Y, Wang Z, Xiao Y, Hu A.   +5 more
europepmc   +1 more source