Results 91 to 100 of about 954,912 (290)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

An Investigation into the Pull-out Failure Mechanisms of Suction Caissons

International Journal of Maritime Technology, 2015
This paper reports results from an investigation into the suction caissons failure mechanisms under vertical pull-out loads. An insight to the failure mechanisms of suction caissons paves the path for developing analytical solutions to their pull-out ...
Mostafa zeinoddini, Mahmood Nabipour, Hamid Matin Nikoo   +2 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Reliability Evaluation Method for Aeroengine Turbine Rotor Assemblies Considering Interaction of Multiple Failure Modes

Actuators
In complex mechanical systems involving multiple parts and contact interfaces, failure modes are not only statistically correlated but may also interact through underlying physical mechanisms.
Xudong Han, Zhefu Yang, Weifeng Zhang, Xueqi Chen, Yanhong Ma, Jie Hong   +5 more
doaj   +1 more source

Thermal barrier coating life prediction model development [PDF]

The objectives are to determine the predominant modes of degradation of a plasma sprayed thermal barrier coating system, and then to develop and verify life prediction models accounting for these degradation modes.
Duderstadt, E. C., Hillery, R. V., Pilsner, B. H.   +2 more
core   +1 more source

Inherent Problems in Designing Two-Failure Tolerant Electromechanical Actuators [PDF]

, 1984
An electromechanical ac-powered rotary actuated four-bar linkage system for rotating the Shuttle/Centaur deployment adapter is described. The essential features of the deployment adapter rotation system (DARS) are increased reliability for mission ...
Hornyak, S.
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

System reliability analysis of bedrock-soil layer slopes subject to seismic action based on the upper bound limit analysis method

Geomatics, Natural Hazards & Risk
Bedrock-soil layer slopes (BSLSs) are widely distributed in nature. The existence of the interface between bedrock and soil layer (IBSL) affects the failure modes of the BSLSs, and the seismic action makes the failure modes more complex.
Qiangshan Yu, Yingbin Zhang, Dejian Li, Qiang Chen, Lirong Lin, Shihao Zhang, Wentao Jia   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source