Results 171 to 180 of about 954,912 (290)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Experimental investigation on deformation behavior and failure modes of limestone under coupled effects of water content and end friction. [PDF]

Sci Rep
Lou P, Sun L, Pan C, Zhang B, Li Y, Xie W.   +5 more
europepmc   +1 more source

Survival Analysis and Failure Modes of Total Hip Arthroplasty Using a Cemented Semi-Retentive Acetabular Cup. [PDF]

J Clin Med, 2023
Stan G, Roman MD, Orban H, Georgeanu VA, Deculescu RS, Brinduse LA, Gheorghiu N.   +6 more
europepmc   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Experimental Study of the Dynamic Compressive and Tensile Anisotropic Mechanical Properties and Failure Modes of Shale. [PDF]

Sensors (Basel)
Dong Q, Tong H, Sun J, Peng S, Jia J.
europepmc   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Real-time gated proton therapy: Introducing clinical workflow and failure modes and effects analysis (FMEA). [PDF]

Tech Innov Patient Support Radiat Oncol
Koh WYC, Tan HQ, Lew KS, Kor WTA, Samsuri NAB, Chan JWS, Chua CGA, Lee JKH, Wibawa A, Master Z, Park SY.   +10 more
europepmc   +1 more source

Influence of the Welding Degree on the Strength and Failure Modes of Tuff. [PDF]

Materials (Basel), 2022
Li L, Li C, Huang B, Wang M, Bai Z, Qi S.   +5 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Failure modes affected by stress concentration in gneiss: laboratory triaxial experiment and numerical reproduction. [PDF]

Sci Rep
Guo L, Zhang B, Huang K, Song D, Chen J, Liu X, Zhang H, Xu G.   +7 more
europepmc   +1 more source