FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Failure Rate and Early Complications of Thumb Carpometacarpal Joint Replacement-A Multicenter Retrospective Study of Two Modern Implant Designs. [PDF]
J Clin Med, 2023 Farkash U +5 more
europepmc +1 more source
Large Sample Estimates and Uniform Confidence Bounds for the Failure Rate Function Based on a Naive Estimator. [PDF]
, 1978 J. Sethuraman, Nozer D. Singpurwalla
openalex +1 more source
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
Predicting Heart Failure with Attention Learning Techniques Utilizing Cardiovascular Data [PDF]
arXivCardiovascular diseases (CVDs) encompass a group of disorders affecting the heart and blood vessels, including conditions such as coronary artery disease, heart failure, stroke, and hypertension. In cardiovascular diseases, heart failure is one of the main causes of death and also long-term suffering in patients worldwide. Prediction is one of the risk
arxiv
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
Advancing Autonomous Vehicle Safety: A Combined Fault Tree Analysis and Bayesian Network Approach [PDF]
arXivThis paper integrates Fault Tree Analysis (FTA) and Bayesian Networks (BN) to assess collision risk and establish Automotive Safety Integrity Level (ASIL) B failure rate targets for critical autonomous vehicle (AV) components. The FTA-BN integration combines the systematic decomposition of failure events provided by FTA with the probabilistic reasoning
arxiv
EFFECT OF STRAIN RATE ON THE TENSILE FAILURE OF WOVEN REINFORCED POLYESTER RESIN COMPOSITES [PDF]
, 1985 L. M. Welsh, J.E. Harding
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Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins
FEBS Open Bio, EarlyView.With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet +6 more
wiley +1 more source
A potential biomarker of cognitive impairment: The olfactory dysfunction and its genes expression
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1884-1897, December 2022., 2022 Abstract Objective Accumulation evidence has reported that olfactory impairment may be an essential clinical marker and predictor of mild cognitive impairment or Alzheimer's disease. Method Participants were enrolled in the population‐based, prospective study in Fuxin county, Liaoning province, China between 2019 and 2021.
Jiayi Song +11 more
wiley +1 more source