Results 151 to 160 of about 4,461,053 (307)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

High failure rate in <i>Pseudomonas aeruginosa</i>-associated periprosthetic hip and knee joint infections. [PDF]

J Bone Jt Infect
Akcicek E, Mitterer JA, Achatz V, Szirmay T, Sebastian S, Hofstaetter JG.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Impact Analysis of the Market Penetration Rate of Connected Vehicles and the Failure Rate of Roadside Equipment on Data Accuracy. [PDF]

Sensors (Basel)
Zhan F.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

High and strikingly early failure-rate following gram-negative periprosthetic joint infection - a retrospective cohort study on 72 cases. [PDF]

Arch Orthop Trauma Surg
Schlossmacher B, Mathes B, Lallinger V, Mueller D, von Eisenhart-Rothe R, Lazic I.   +5 more
europepmc   +1 more source

Failure Rate and Early Complications of Thumb Carpometacarpal Joint Replacement-A Multicenter Retrospective Study of Two Modern Implant Designs. [PDF]

J Clin Med, 2023
Farkash U, Sakhnini M, Dreyfuss D, Tordjman D, Rotem G, Luria S.   +5 more
europepmc   +1 more source

Student Failure Rates [PDF]

Nature, 1964
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Repeat spinal anesthesia for intrapartum cesarean section after epidural labor analgesia: a retrospective cohort study of failure rate and the volume-risk relationship. [PDF]

BMC Anesthesiol
Wei Y, Liu K, Lu X, Wang J, Li J, Yao L.
europepmc   +1 more source