Results 81 to 90 of about 14,277,999 (385)

Failure Analysis and Quantification for Contemporary and Future Supercomputers [PDF]

arXiv, 2019
Large-scale computing systems today are assembled by numerous computing units for massive computational capability needed to solve problems at scale, which enables failures common events in supercomputing scenarios. Considering the demanding resilience requirements of supercomputers today, we present a quantitative study on fine-grained failure ...
arxiv  

Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies

Annals of Neurology, 2018
Blunted tachycardia during hypotension is a characteristic feature of patients with autonomic failure, but the range has not been defined. This study reports the range of orthostatic heart rate (HR) changes in patients with autonomic failure caused by ...
L. Norcliffe-Kaufmann, H. Kaufmann, J. Palma, C. Shibao, I. Biaggioni, A. Peltier, W. Singer, P. Low, D. Goldstein, C. Gibbons, R. Freeman, D. Robertson   +11 more
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Image quality comparisons of coil setups in 3T MRI for brain and head and neck radiotherapy simulations

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose MRI is increasingly used for brain and head and neck radiotherapy treatment planning due to its superior soft tissue contrast. Flexible array coils can be arranged to encompass treatment immobilization devices, which do not fit in diagnostic head/neck coils. Selecting a flexible coil arrangement to replace a diagnostic coil should rely
Evangelia Kaza, Jeffrey P. Guenette, Christian V. Guthier, Steven Hatch, Alexander Marques, Lisa Singer, Jonathan D. Schoenfeld   +6 more
wiley   +1 more source

Computer-modified paramedian approach technique reduces failures and alleviates pain in lumbar puncture: a prospective comparative study

Frontiers in Medicine
BackgroundThe conventional midline approach for lumbar puncture (MAT-LP) has a relatively low success rate of 70%. The paramedian approach can increase the effective puncture area and success rate but lacks standardized guidelines. This study evaluated a
Yuan-Dong Zhuang, Hai-Shu Xie, Jing Chen, Guo-Hua Wu, Jian-Feng Wu, Jian-Feng Wu, Chun-Mei Chen, Chun-Mei Chen   +7 more
doaj   +1 more source

An Examination of the Failure Rate and Content Equivalency of Electronic Surrogates and the Implications for Print Equivalent Preservation

Evidence Based Library and Information Practice, 2010
Objective – This study sought to determine whether evidence indicates a need to preserve print equivalent journal collections. In addition, this research aimed to provide data on the failure rate of print equivalent materials for possible digitization to
Ken Ladd
doaj   +1 more source

Transcatheter Mitral‐Valve Repair in Patients with Heart Failure

New England Journal of Medicine, 2018
BACKGROUND Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor. Transcatheter mitral‐valve repair may improve their clinical outcomes.
G. Stone, J. Lindenfeld, W. Abraham, S. Kar, Scott Lim, Jacob M. Mishell, B. Whisenant, P. Grayburn, M. Rinaldi, S. Kapadia, V. Rajagopal, I. Sarembock, A. Brieke, S. Marx, D. Cohen, N. Weissman, M. Mack   +16 more
semanticscholar   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Clinical commissioning of an adaptive radiotherapy platform: Results and recommendations

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Online adaptive radiotherapy platforms present a unique challenge for commissioning as guidance is lacking and specialized adaptive equipment, such as deformable phantoms, are rare. We designed a novel adaptive commissioning process consisting of end‐to‐end tests using standard clinical resources.
Kelly Kisling, Timothy D. Keiper, Daniela Branco, Grace Gwe‐Ya Kim, Kevin L Moore, Xenia Ray   +5 more
wiley   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source