Results 81 to 90 of about 4,436,913 (350)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Completely monotone regression estimates of software failure rates [PDF]
A method for estimating the present failure rate of a program is presented. A crude nonparameter estimate of the failure rate function is obtained from past failure times.
Miller, D. R., Sofer, A.
core +1 more source
Fracture size effects in nanoscale materials: the case of graphene
, 2015 Nanoscale materials display enhanced strength and toughness but also larger fluctuations and more pronounced size effects with respect to their macroscopic counterparts.
Sellerio, Alessandro Luigi +2 more
core +1 more source
To Burn-In, or Not to Burn-In: That’s the Question
Aerospace, 2019 In this paper it is shown that the bathtub-curve (BTC) based time-derivative of the failure rate at the initial moment of time can be considered as a suitable criterion of whether burn-in testing (BIT) should or does not have to be conducted.
Ephraim Suhir
doaj +1 more source
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
A new engineering approach to predict the hydrostatic strength of uPVC\ud pipes [PDF]
, 2007 Extruded unplasticised Poly(Vinyl Chloride) (uPVC) pipes are certified using pressurised pipe tests.\ud During these tests the pipes are subjected to a certain temperature and internal pressure, while the\ud time-to-failure, the time at which the ...
Bor, T.C. +3 more
core +2 more sources
Standardization of cumulative failure rates [PDF]
Demography, 1975 Abstract A method is proposed for standardizing life table cumulative failure rates for various cohorts so that they are adjusted to the distribution of exposure by age group for a particular cohort. An approximate standard error for the standardized cumulative failure rate is presented. Application of the methodology is illustrated by a
openaire +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Temporal-varying failures of nodes in networks
, 2015 We consider networks in which random walkers are removed because of the failure of specific nodes. We interpret the rate of loss as a measure of the importance of nodes, a notion we denote as failure-centrality. We show that the degree of the node is not
Altmann, Eduardo G. +2 more
core +1 more source
IEEE Access, 2019 The offshore wind farms (OWF) are susceptible to the severe weather, which can cause the increase of component failure rate and has significant influence on the maintenance process and the reliability of wind farms.
Huawei Chao +5 more
doaj +1 more source