Results 111 to 120 of about 1,114,787 (316)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

The Qur’anic Concept of Leadership: A Contextual Analysis of the Intertextual Relationship among Qur’anic Verses on Leadership

open access: yesAfkaruna: Indonesian Interdisciplinary Journal of Islamic Studies
This article examined the concept of leadership in the Quran, focusing on the word caliph, which appears twice: in Surah Al-Baqarah, verse 30, and Surah Sad, verse 26. In Surah Al-Baqarah, the word caliph refers to Adam, whom Allah endowed with knowledge,
Hadiyan   +3 more
doaj   +1 more source

OTHER TITLES: Kansas State Fair Premium Book, '86, Sept. 5-14, Hutchinson. Kansas State Fair 1986 Premium Book. 1986 Premium Book.

open access: yes, 1986
Issued in four volumes: 4-H Agriculture-Youth-Domestic Arts Horses Livestock "In tribute to the 125th birthday of Kansas."Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding
Kansas State Fair.
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Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

OTHER TITLES: Kansas State Fair 1993 Premium Book. 1993 Premium Book.

open access: yes, 1993
Issued in four volumes: Agriculture-Domestic Arts Horses Livestock Youth.Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair, held once a year in ...
Kansas State Fair.
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Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

QFlowCrate: A QGIS Plugin for Workflow Documentation and Provenance Capture to Enhance Geoscientific Reproducibility

open access: yesJournal of Open Research Software
We present QFlowCrate, a QGIS plugin designed to support semi-automatic documentation of geospatial workflows and improve map reproducibility. Addressing the lack of integrated provenance capture in desktop GIS, QFlowCrate retrospectively records data ...
Andreas Rademaker   +2 more
doaj   +1 more source

OTHER TITLE: Kansas State Fair Premium Book, '85, Hutchinson, Sept. 6-15, 1985. 1985 Premium Book.

open access: yes, 1985
Issued in four volumes: 4-H Agriculture-Youth-Domestic Arts Horses Livestock.Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair, held once a year in ...
Kansas State Fair.
core  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

OTHER TITLES: Premium Book: the Kansas State Fair, 80, Hutchinson, Sept. 6-14. 1980 Premium Book.

open access: yes, 1980
Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair, held once a year in Hutchinson Kansas.Index 1980 Kansas State Fair Program Highlights Welcome To
Kansas State Fair.
core  

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