Results 101 to 110 of about 1,112,630 (316)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 1988 Issued in four volumes: Agriculture-Domestic Arts Horses Livestock Youth.Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair, held once a year in ...
Kansas State Fair.
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2016 Dans les planches de l’Encyclopédie, le voir ouvre l’accès universel au savoir. La beauté du mécanisme est un modèle d’intelligibilité, et à ce titre elle contribue à opposer les connaissances scientifiques à toutes sortes de savoirs occultes. La machine est en effet comparable à l’œuvre d’art en tant qu’un faire intelligent, tandis que les machines d ...
openaire +1 more source
OTHER TITLE: 2001 Kansas State Fair Odyssey, September 7-16, 2001, Hutchinson.
, 2001 Issued in four volumes: Agriculture-Domestic Arts Horses Livestock Youth. "www.kansasstatefair.com"Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair,
Kansas State Fair.
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Collaborative Effort Towards a FAIR and OPEN Indo-Pacific Pollen Database (IPPD)
Data Science JournalThe Indo-Pacific Pollen Database (IPPD) is a collection of modern and fossil Australian, Southeast Asian, and Oceanian pollen assemblages collected from Quaternary period depositional contexts. This compilation has been in the making since the late 1980s
Annika V. Herbert +3 more
doaj +1 more source
, 1998 Issued in four volumes: Agriculture-Domestic Arts Horses (MISSING PAGES) Livestock Youth "Party on the Prairie!"Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the ...
Kansas State Fair.
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source