Results 81 to 90 of about 2,066,018 (309)

Evaluation of Uncertainties in the Design Process of Complex Mechanical Systems

Entropy, 2017
In this paper, the problem of the evaluation of the uncertainties that originate in the complex design process of a new system is analyzed, paying particular attention to multibody mechanical systems. To this end, the Wiener-Shannon’s axioms are extended
Francesco Villecco, Arcangelo Pellegrino
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Fair division with general equilibrium effects and international climate politics [PDF]

This paper introduces a solution for the fair division of common property resources in production economies with multiple inputs and outputs. It is derived from complementing the Walrasian solution by welfare bounds, whose ethical justification rests on ...
Helm, Carsten, Böhringer, Christoph
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MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Channel Asymmetry in Cellular OFDMA-TDD Networks

EURASIP Journal on Wireless Communications and Networking, 2009
This paper studies time division duplex- (TDD-) specific interference issues in orthogonal frequency division multiple access- (OFDMA-) TDD cellular networks arising from various uplink (UL)/downlink (DL) traffic asymmetries, considering both line-of ...
Harald Haas, Patrick Agyapong, Ellina Foutekova   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

N-Person cake-cutting: there may be no perfect division [PDF]

A cake is a metaphor for a heterogeneous, divisible good, such as land. A perfect division of cake is efficient (also called Pareto-optimal), envy-free, and equitable.
Brams, Steven J., Jones, Michael A., Klamler, Christian   +2 more
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Intrahepatic Reactive Lymphoid Hyperplasia: A Case Report and Review of the Literature

Case Reports in Surgery, 2018
Introduction. Reactive lymphoid hyperplasia (RLH) is a rare and benign lesion found in organs of the gastrointestinal tract, skin, lung, orbit, and more rarely in the liver.
Samantha Seitter, Zachary D. Goodman, Theodore M. Friedman, Timothy R. Shaver, George Younan   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

OTHER TITLES: Kansas State Fair 1982 Premium Book, Hutchinson, Sept. 11-19. 1982 Premium Book.

, 1982
Issued in four volumes: 4-H Agriculture-Youth-Domestic Arts Horses Livestock.Program of State Fair events. Also contains rules, regulations, classes of events, prizes, and other pertinent information regarding the Kansas State Fair, held once a year in ...
Kansas State Fair.
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